Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors

ABSTRACT

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a continuation of U.S. patent applicationSer. No. 15/611,203, filed on Jun. 1, 2017, which is a continuation ofU.S. patent application Ser. No. 15/164,430, filed on May 25, 2016,issued as U.S. Pat. No. 9,670,207, which is a continuation of U.S.patent application Ser. No. 14/725,683, filed on May 29, 2015, issued asU.S. Pat. No. 9,402,833, which is a divisional of U.S. patentapplication Ser. No. 14/364,451, filed on Jun. 11, 2014, issued as U.S.Pat. No. 9,045,478, which application is a national phase entry under 35U.S.C. § 371 of International Application No. PCT/IB2012/003012 filed onDec. 12, 2012, published in English, which claims the priority fromIndian Patent Application No. 4329/CHE/2011, filed on Dec. 12, 2011, thedisclosures of which are incorporated herein by reference.

TECHNICAL FIELD

The present application relates to a series of substitutedpyrazolo[1,5-a]pyridine compounds. The present application is furtherdirected to use such compounds as tropomyosin receptor kinase (Trk)family protein kinase inhibitors. The present application also describesmethod of making such compounds and pharmaceutical compositionscomprising such compounds.

BACKGROUND

TrkA, TrkB and TrkC, which make up the Trk receptor family, are highaffinity receptor tyrosine kinases activated by a group of solublegrowth factors called neurotrophins (NT) (Curr Opin Neurobiol, 2001, 11,272-280).

Inhibitors of the Trk/neurotrophin pathway have been demonstrated to beeffective in numerous animal models of pain. For example, sustainedblockade of neurotrophin receptors TrkA, TrkB and TrkC reducesnon-malignant skeletal pain (Bone, 2011, 48(2), 389-398). Administrationof NGF receptor (TrkA) inhibitor K252a showed significant suppression ofmechanical hyperalgesia (relevant to the pathogenesis of myofascial painsyndrome (MPS)) in animal models (J. Pain, Article in Press, 2011,12(10), 1059-1068). Antagonistic NGF and TrkA antibodies have been shownto be efficacious in inflammatory and neuropathic pain animal models(Neuroscience, 1994, 62, 327-331; J. Pain, 2004, 5, 157-163; Nat. Med.,1995, 1, 774-780; Pain, 2005, 116, 8-16; Pain, 2003, 105, 489-497) andneuropathic pain animal models (Eur. J. Neurosci., 1999, 11, 837-846;Pain, 1999, 79, 265-274; Pain, 1999, 81, 245-255; Neurosci. Lett., 2003,336, 117-120).

NGF secreted by tumor cells and tumor invading macrophages has beenshown to directly stimulate TrkA located on peripheral pain fibers. Ithas also been demonstrated in various tumor models in both mice and ratsthat neutralizing NGF with a monoclonal antibody inhibits cancer relatedpain. Further, activation of the BDNF/TrkB pathway has been implicatedin numerous studies as a modulator of various types of pain includinginflammatory pain (J. Physiol. 2005, 569:685-95), neuropathic pain(Proc. Natl. Acad. Sci. USA 1999, 96:7714-18) and surgical pain(Molecular Pain, 2008, 4(28), 1-11). Since TrkA kinase has beendemonstrated to serve as a mediator of NGF driven biological responses,inhibitors of TrkA and/or other Trk kinases may provide an effectivetreatment for various pain conditions.

Inhibition of the neurotrophin/Trk pathway with NGF antibodies ornon-selective small molecule inhibitors of Trk A, B and C has been shownto be effective in treatment of pre-clinical models of inflammatorydiseases such as asthma (Pharmacol. Therapeut., 2008, 117(1), 52-76),interstitial cystitis (J. Urology, 2005, 173(3), 1016-21), inflammatorybowel diseases including ulcerative colitis and Crohn's disease (Gut,2000, 46(5), 670-678) and inflammatory skin diseases such as atopicdermatitis (Arc Dermatol Res., 2006, 298(1), 31-37), eczema andpsoriasis (J. Investig Dermatol., 2004, 122(3), 812-819).

The current treatment regimes for pain conditions utilize severalclasses of compounds. The opiates apart from being potentially addictivehave several adverse effects such as emesis, constipation, dose-relatedrespiratory depression. Nonsteroidal anti-inflammatory analgesics(NSAID) also have drawbacks such as gastric ulceration, dyspepsia andinsufficient efficacy in treating severe pain. Accordingly, there is acontinuing need for new and more effective treatments for the relief ofpain, especially chronic pain. Several classes of small moleculeinhibitors of Trk kinases said to be useful for treating pain or cancerare known (Expert Opin. Ther. Patents, 2009, 19(3), 305-319).

U.S. Publication No. 20110195948 describes substitutedpyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors.

JP Publication No. 2003231687 describes a series of pyrazolyl condensedcyclic compounds as Trk inhibitors.

PCT Publication No. 200505427 describes compounds containing a1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole bicyclic scaffold as TrkAinhibitors.

PCT Publication No. 2004011461 describes a series of isothiazolederivatives as Trk inhibitors.

SUMMARY

The present applications relates to pyrazolo[1,5-a]pyridine compounds offormula (I),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein

-   -   A is

X¹ is CH or N;

-   -   R¹ represents hydrogen or —(C₁-C₆)alkyl;    -   R² is independently selected from hydrogen, halogen, cyano,        —(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl, -halo(C₁-C₆)alkoxy, phenyl        optionally substituted with 1 to 3 halogens or an optionally        substituted —O-heterocyclyl wherein the optional substituent is        selected from alkyl, —OR^(i) or —C(O)N(R^(i))₂;    -   when X¹ is CH, optionally two R²s present on any two adjacent        carbon atoms combine to form a 5 to 7 membered heterocyclic        ring;    -   R³ is independently selected from halogen, cyano, —OR^(i),        —C(O)N(R^(i))₂ or two R³s together with the carbon atom they are        attached form a (C₃-C₇)cycloalkyl group spiro attached to        pyrrolidine; or two R³ when they are attached to adjacent carbon        atoms form a (C₃-C₇)cycloalkyl ring fused to the pyrrolidine;    -   R^(a) is selected from        -   (i) a group selected from optionally substituted            —(C₁-C₆)alkyl, -hydroxy(C₁-C₆)alkyl or            —(C₁-C₆)alkyl-(C₁-C₆)alkoxy wherein the optional            susbstituent is selected from cyano, halogen or            —(C₆-C₁₂)aryl,        -   (ii) an optionally substituted —(C₃-C₁₀)cycloalkyl wherein            the optional substituent is selected from cyano,            —(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s),        -   (iii) an optionally substituted —(C₆-C₁₂)aryl wherein the            optional substituent is selected from cyano, hydroxyl,            halogen, —(C₁-C₆)alkyl or —R^(r)        -   (iv) an optionally substituted 5 to 10 membered heterocyclyl            wherein the optional substituent is selected from cyano,            hydroxyl, halogen or —(C₁-C₆)alkyl,        -   (v) an optionally substituted 5 to 10 membered heteroaryl            wherein the optional substituent is selected from cyano, oxo            (═O), hydroxyl, halogen, —(C₁-C₆)alkyl, —(C₁-C₆)alkoxy,            —NR^(c)R^(d) or —R^(r),        -   (vi) —NR⁴R⁵,        -   (vii) —(C₁-C₆)alkyl-(C₆-C₁₂)aryl;    -   R^(b) represents hydrogen or halogen;    -   R⁴ is selected from hydrogen, —(C₁-C₆)alkyl,        —(C₃-C₁₀)cycloalkyl, -hydroxy(C₁-C₆)alkyl, -alkoxy(C₁-C₆)alkyl,        -halogen(C₁-C₆)alkyl or —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl;    -   R⁵ is selected from hydrogen or —(C₁-C₆)alkyl or        —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl;    -   Alternatively R⁴ and R⁵ together with the nitrogen atom to which        they are attached may form an optionally substituted 5 to 10        membered heterocyclic ring optionally containing 1-2 additional        heteroatoms or groups selected from —O—, —S—, —N—, —C(═O)—,        —S(═O)— or —S(═O)₂—, wherein the optional substituent is        selected from hydroxyl, —(C₁-C₆)alkyl, —C(═O)—(C₁-C₆)alkyl,        mesyl or COOR^(e);    -   R^(c) and R^(d) are independently selected from hydrogen or        —(C₁-C₆)alkyl;    -   R^(e) is selected from hydrogen or alkyl;    -   R^(i) is hydrogen, —(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl,        —(C₁-C₆)alkyl-(C₁-C₆)alkoxy, —(C₃-C₁₀)cycloalkyl, optionally        substituted —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl wherein the        optional substituent is halogen or —(C₁-C₆)alkyl substituted        with 1 to 3 hydroxy groups;    -   R^(r) is independently selected from a 5 to 10 membered        heterocyclyl or a 5 to 10 membered heteroaryl, wherein optional        substituent is selected from hydroxyl, halogen, —(C₁-C₆)alkyl or        —(C₁-C₆)alkoxy;    -   R^(s) is an optionally substituted —(C₁-C₆)alkyl-(C₆-C₁₀)aryl,        wherein the optional substituent is halogen;    -   m is independently represents 0, 1, 2, 3 or 4; and    -   n is independently represents 0, 1, 2, or 3.

The present application further relates to methods of treating orpreventing conditions, diseases and/or disorders associated withabnormal or deregulated Trk kinase activity by administereing effectiveamount of a compound of formula (I), to a patient in need thereof.

One aspect of the present application provides methods of treating orpreventing conditions, diseases and/or disorders associated withabnormal or deregulated TrkA kinase activity by administereing effectiveamount of a compound of formula (I), to a patient in need thereof.

One aspect of the present application provides conditions. diseasesand/or disorders treatable or preventable by inhibition of Trk kinaseactivity, such as pain, inflammation, cancer, restenosis,atherosclerosis, psoriasis, thrombosis, psoriatic arthritis, rheumatoidarthritis, inflammatory bowel disease, ulcerative colitis, Crohn'sdisease, fibrosis, neurodegenerative disease or a disease, disorder orinjury relating to dysmyelination or demyelination by administering atherapeutically effective amount of compound of formula (I), to apatient in need thereof.

The present application also relates to pharmaceutical compositionscomprising effective amount of a compound of formula (I), and apharmaceutically acceptable carrier or diluent, and the use of suchcompositions in the treatment and/or prevention of diseases associatedwith inhibiting TrkA in a patient in need thereof, such as pain,inflammation, cancer, restenosis, atherosclerosis, psoriasis,thrombosis, psoriatic arthritis, rheumatoid arthritis, inflammatorybowel disease, ulcerative colitis, Crohn's disease, fibrosis,neurodegenerative disease, a disease, disorder, or injury relating todysmyelination or demyelination or certain infectious diseases such asTrypanosoma cruzi infection

DETAILED DESCRIPTION

As used herein, ‘halogen or halo’ group refers to fluorine, chlorine,bromine or iodine.

As used herein, ‘(C₁-C₆)alkyl’ refers to linear or branched alkyl groupwith 1 to 6 carbon atoms. Exemplary (C₁-C₆)alkyl group includes, but isnot limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl,t-butyl, n-pentyl, iso-pentyl and the like. (C₁-C₃)alkyl refers tolinear or branched alkyl group having one to three carbon atoms such asmethyl, ethyl propyl or iso-propyl.

As used herein, ‘hydroxy(C₁-C₆)alkyl’ refers to a group wherein at leastone hydrogen atom of an (C₁-C₆)alkyl group is replaced by a hydroxylgroup. (C₁-C₆)alkyl group is as defined above. Representative examplesof hydroxy(C₁-C₆)alkyl groups include one or more of, but are notlimited to hydroxymethyl, hydroxyethyl and the like. Unless otherwisespecified, a hydroxy(C₁-C₆)alkyl group is having 1 to 6 carbon atoms. Asused herein, ‘halo(C₁-C₆)alkyl’, in each occurrence, independently meansat least one hydrogen atom of an (C₁-C₆)alkyl group is replaced by ahalogen group. Halogen and (C₁-C₆)alkyl group are as defined above.Representative examples of halo(C₁-C₆)alkyl groups include one or moreof, but are not limited to fluoromethyl, difluoromethyl, fluroethyl,difluroethyl, trifluloethyl, fluoropropyl, difluoropropyl,trifluoropropyl and the like.

As used herein ‘(C₃-C₁₀)cycloalkyl’ refers to a cyclic alkyl group whichmay be mono, bicyclic, polycyclic, or a fused/bridged ring system having3 to 10 carbon atoms. Exemplary cycloalkyl groups include, but are notlimited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl,cycloheptyl, cyclooctyl, and the like. Typical bridged cycloalkylsinclude, but are not limited to adamantyl, noradamantyl,bicyclo[1.1.0]butanyl, norbornyl(bicyclo[2.2.1]heptanyl), and the like.

As used herein, two R³s when they are attached two adjacent carbon atomsform (C₃-C₇)cycloalkyl spiro attached to pyrrolidine are selected fromcyclopropyl, cyclobutyl and the like.

As used herein, ‘(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl’ refers to a groupwherein (C₁-C₆)alkyl group is optionally substituted with at least one(C₃-C₁₀)cycloalkyl, wherein (C₁-C₆)alkyl and (C₃-C₁₀)cycloalkyl are asdefined above. Exemplary (C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl groups includemethyl-cyclobutyl, ethyl-clcobutyl and the like.

As used herein, ‘(C₁-C₆)alkoxy’ refers to an —O—(C₁-C₆)alkyl group,wherein (C₁-C₆)alkyl group is as defined above. Exemplary (C₁-C₆)alkoxygroups include methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy,iso-butoxy, t-butoxy, and the like. (C₁-C₃)alkoxy refers to an alkoxygroup having one to three carbon atoms, such as methoxy, ethoxy, propoxyor isopropoxy.

As used herein, ‘halo(C₁-C₆)alkoxy’ refers to a group wherein at leastone hydrogen atom of an (C₁-C₆)alkoxy group is replaced by a halogengroup. Halogen and (C₁-C₆)alkoxy group are as defined above.Representative examples of halo(C₁-C₆)alkoxy groups include one or moreof, but are not limited to fluoromethoxy, difluoromethoxy, fluroethoxy,difluroethoxy, trifluloethoxy, fluoropropoxy, difluoropropoxy,trifluoropropoxy and the like.

As used herein, ‘(C₆-C₁₂)aryl’ refers to a monocyclic or polycyclicaromatic ring system having 6 to 12 carbon atoms. Exemplary aryl groupsinclude, but are not limited to, phenyl, naphthyl, and the like.

As used herein, ‘aralkyl’ refers to an (C₁-C₆)alkyl group substitutedwith at least one (C₆-C₁₂)aryl group, wherein (C₁-C₆)alkyl and(C₆-C₁₂)aryl groups are as defined above. Exemplary aralkyl groupsinclude, but are not limited to, benzyl, ethyl-phenyl and the like.(C₁-C₃)alkyl-(C₆-C₁₂)aryl groups refers to an (C₁-C₃)alkyl groupsubstituted with at least one (C₆-C₁₂)aryl group, wherein (C₁-C₃)represents an alkyl group having 1 to 3 carbon atoms and (C₆-C₁₂)arylgroup is as defined above. Exemplary (C₁-C₃)alkyl-(C₆-C₁₂)aryl groupsinclude methyl-phenyl, ethyl-phenyl and the like.

As used herein, ‘5 to 10 membered heterocyclyl’ or ‘5 to 10 memberedheterocyclic ring’ refers to a monocyclic or polycyclic ring system,having at least one heteroatom or heterogroup selected from O, N, S, SO,SO₂, or CO. Exemplary heterocyclyl or heterocyclic ring groups include,but not limited to, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl,tetrahydrofuranyl, tetrahydro-2H-pyranyl, morpholinyl, thiomorpholinyl,thiomorpholine-1,1-dioxide, tetrahydro-2H-thiopyranyl, thiazolidinyl,1,3-dioxolanyl, 1,4-dioxanyl, 1-oxidotetrahydro-2H-thiopyranyl,1,1-dioxidotetrahydro-2H-thiopyranyl,hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl,2,5-diazabicyclo[2.2.1]heptan-2-yl, azepanyl and the like.

As used herein, ‘5 to 7 membered heterocyclyl’ or ‘5 to 7 memberedheterocyclic ring’ refers to a monocyclic ring system, having at leastone heteroatom or heterogroup selected from O, N, S, SO, SO₂, or CO.Exemplary heterocyclyl or heterocyclic ring groups include, but notlimited to, 1,4-dioxane, 1,4-dioxepane and the like.

As used herein, ‘5 to 10 membered heteroaryl group’ refers to amonocyclic or polycyclic ring system, unsaturated, aromatic ornon-aromatic; having at least one heteroatom or heterogroup selectedfrom —O—, —N—, —S—, —S(═O)—, —S(═O)₂, or —C(═O)—. Exemplary heteroarylring groups, aromatic or non-aromatic rings, include, but not limitedto, furanyl, oxazolyl, isoxazole, imidazolyl, triazolyl, thiophenyl,thiazolyl, pyridinyl, thiazinyl, pyrazinyl, pyrazolyl, tetrazolyl,imidazothiazolyl, furanyl, oxazolyl, isoxazole, imidazolyl, oxadiazolyl,triazolyl, thiazolyl, pyridinyl, thiazinyl, pyrazinyl, pyrazolyl,tetrazolyl, imidazothiazolyl, indolizidinyl, indolinyl, oxoindolinyl,indolyl, oxoindolyl, quinolinyl, 3,4-dihydroisoquinolin-2(1H)-yl,quinoxalinyl, benzoxazolyl, benzo[d]isoxazolyl, benzo[d]thiazolyl,benzo[d][1,3]dioxolyl, 1H-benzo[d][1,2,3]triazolyl, 2H-indazolyl,1H-indazolyl, quinoxalin-2-yl, 1H-benzo[d]imidazolyl,pyrazolo[1,5-a]pyridinyl, dihydrobenzo[b][1,4]dioxinyl,(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-yl),4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazinyl,5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl),5,6,7,8-tetrahydroimidazo[1,2-a]pyrazinyl,Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl,5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazinyl, pyrazolo[1,5a]pyridinyl andthe like.

The Trk's are made up of three family members TrkA, TrkB and TrkC thatbind to and mediate the the signal transduction derived from theNeurotrophins. Inhibitors of the Trk/neutrophin pathway have beendemonstrated to be highly effective in numerous pre-clinical animalmodels of pain. The compounds of the invention are modulators of the Trkreceptors, particularly TrkA.

As used herein, the term TrkA refers to one of Trk's high affinitybinding protein kinase receptors that are activated by Neurotrophins(NT), a group of soluble growth factors Nerve Growth Factor (NGF),Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin 3-5 (NT 3-5).

‘Optionally substituted’ means that the substitution is optional andtherefore it is possible for the designated atom or group to beunsubstituted. In the event a substitution is desired, then suchsubstitution means that any number of hydrogens on the designated atomis replaced with a selection from the indicated group, provided that thenormal valence of the designated atom is not exceeded, and that thesubstitution results in a stable compound. For example, in formula (I)when a substituent is oxo (i.e., ═O), then two hydrogens on the atom arereplaced and when the substitution is fluoro, then one hydrogen on theatom is replaced and the like. When more than one substituent is presenton an atom or group, the chosen substituents are independent of eachother (i.e same or different).

As used herein and in the appended claims, the singular forms “a”, “an”,and “the” include plural reference unless the context clearly indicatesotherwise.

As used herein, the term ‘subject’ or ‘patient’ means mammals, such ashumans and other animals, including horses, dogs, cats, rats, mice,sheep, pigs, monkeys, chimpanzees or other apes or primates. Inexemplary embodiments, the subject may include subjects for whichtreatment and/or prevention of the conditions described herein would bebeneficial.

For ease of reference, in this application it will be described in termsof administration to human subjects. It will be understood, however,that such descriptions are not limited to administration to humans, butwill also include administration to other animals unless explicitlystated otherwise.

A ‘therapeutically effective amount’ is the amount of compound of thepresent application that is effective in generating biological ormedical response of a subject, for example, reduction or inhibition ofan enzyme or a protein activity, or ameliorate symptoms, alleviateconditions, slow or delay disease progression, or prevent a disease.

In one embodiment, the term ‘a therapeutically effective amount’ refersto the amount of the compound of the present application that, whenadministered to a subject, is effective in (i) at least partiallyalleviating, inhibiting, preventing and/or ameliorating a condition, ora disorder or a disease mediated by TrkA, TrkB and/or TrkC, associatedwith TrkA, TrkB and/or TrkC activity or characterized by activity(normal or abnormal) of TrkA, TrkB and/or TrkC; (ii) reducing orinhibiting the activity of TrkA, TrkB and/or TrkC; or (iii) reducing orinhibiting the expression of TrkA, TrkB and/or TrkC.

In another embodiment, the term “a therapeutically effective amount”refers to the amount of the compound of the present invention that, whenadministered to a cell, or a tissue, or a non-cellular biologicalmaterial, or a medium, is effective to at least partially reducing orinhibiting the activity of TrkA, TrkB and/or TrkC; or at least partiallyreducing or inhibiting the expression of TrkA, TrkB and/or TrkC.

The terms ‘treating’ or ‘to treat’ means to alleviate symptoms,eliminate the causation either on a temporary or permanent basis, or toprevent or slow the appearance of symptoms. The term ‘treatment’includes alleviation, elimination of causation of or prevention of anyof the diseases or disorders described above. The compounds describedherein are typically administered in admixture with one or morepharmaceutically acceptable excipients or carriers in the form of apharmaceutical composition. A ‘composition’ may contain one compound ora mixture of compounds. A ‘pharmaceutical composition’ is anycomposition useful in producing at least one physiological response in asubject to which such pharmaceutical composition is administered.

The term ‘substantially pure’ means that the isolated material is atleast 80% pure, preferably 90% pure, more preferably 95% pure, and evenmore preferably 99% pure as measured by a suitable analytical techniquesknown in the art.

Unless defined otherwise, all technical and scientific terms used hereinhave the same meaning as commonly understood to one of ordinary skill inthe art.

One or more compounds of formula (I) can be supplied in the form of atherapeutic composition that is within the scope of the presentapplication.

The term ‘Pharmaceutically acceptable salts’ refers to any acid or basesalt, pharmaceutically acceptable solvates, or any complex of thecompound that, when administered to a recipient, is capable of providing(directly or indirectly) a compound as described herein. It should beappreciated, however, that salts that are not pharmaceuticallyacceptable also lie within the scope of the application. The preparationof salts can be carried out using known methods.

For example, pharmaceutically acceptable salts of compound of formula(I) contemplated refers to salts prepared from acids or bases includinginorganic or organic acids and inorganic or organic bases byconventional chemical methods using a compound of formula (I).Generally, such salts may be prepared, for example, by making free baseof the compounds and reacting with a stoichiometric quantity of theappropriate acid and vice-versa in water or in an organic solvent, or ina mixture of the two. The comounds of the present applications may formmono, di or tris salts.

When the compound of formula (I) is basic, salts may be prepared fromacids, including inorganic or organic acids (acid addition salts).Examples of such acids include, but not limited toformic, acetic,trifluoroacetic, propionic, succinic, glycolic, gluconic, lactic, malic,tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic,aspartic, glutamic, benzoic, anthranilic, mesylic, stearic, salicylic,p-hydroxybenzoic, phenylacetic, mandelic, embonic (pamoic), nitric,hydrochloride, hydrobromide, isoethionic, hydroiodide, phosphoric,sulfuric, succinic, tartaric, methanesulfonic, ethanesulfonic,benzenesulfonic, benzoic, mucic, pantothenic, p-toluenesulfonic,camphorsulfonic, 2-hydroxyethanesulfonic, sulfanilic,cyclohexylaminosulfonic, algenic, β-hydroxybutyric, galactaric, andgalacturonic acid, and the like.

Salts formed from inorganic bases include sodium, potassium, lithium,calcium, copper, magnesium, manganic salts, manganous, zinc, aluminum,ammonium, ferric, ferrous and the like.

Salts derived from organic bases include salts of primary, secondary,and tertiary amines, substituted amines including naturally occurringsubstituted amines, cyclic amines, and basic ion exchange resins, suchas arginine, betaine, caffeine, choline,N,N-dibenzylethylene-diamine_(s) diethylamine, 2-diethylaminoethanol,2-dimethylaminoethanol, ethanolamine, ethylenediamine,N-ethylmorpholine, N-ethylpiperidine, glucamine, glucosamine, histidine,hydrabamine, isopropylamine, lysine, methylgiucamine, morpholine,piperazine, piperid e, polyamine resins, procaine, purines, theobromine,triethylamine, trimethylamine, tripropylamine, tromethamine, and thelike.

‘Pharmaceutically acceptabl salts’ in the solid form may exist in morethan one crystal structure, and may also be in the form of hydrates.

The term ‘stereoisomers’ is a general term used for all isomers of anindividual molecule that differ only in the orientation of their atomsin space. Where the compounds according to the present applicationpossess one or more asymmetric centers and compounds with asymmetriccenters give rise to enantiomers, diastereomers or both as pure orpartially purified compounds. It is to be understood that allstereoisomeric forms of the compounds of the invention, including butnot limited to, diastereomers, enantiomers and atropsiomers, as well asmixtures thereof such as forms, are included in the scope of the presentapplication. Preparation of such stereoisomeric forms of compound offormula (I), may be achieved by appropriate modification of themethodology known in the art. Their absolute stereochemistry may bedetermined by the suitable methods. If required, racemic mixtures of thecompound of formula (I) may be separated to isolate individualenantiomers or diastereomers. Such separation can be carried out bymethods known in the art, such as the coupling of a racemic mixture ofcompound of formula (I) to an enantiomerically pure compound to form adiastereomeric mixture, followed by separation of the individualdiastereomers by standard methods, such as fractional crystallization orchromatography. The coupling reaction is often the formation of saltsusing an enantiomerically pure acid or base. The diastereomericderivatives may then be converted to the pure enantiomers by cleavage ofthe added chiral residue. The racemic mixture of the compounds can alsobe separated directly by chromatographic methods using chiral stationaryphases, which methods are well known in the art. Alternatively, anyenantiomer or diastereomer of a compound may be obtained bystereoselective synthesis using optically pure starting materials orknown reagents.

For any particular compound disclosed herein, wherein thestereochemistry of any particular chiral atom is not specified, then allstereoisomers are contemplated and included as the compounds of theapplication. Where stereochemistry is specified by a solid wedge or adashed wedge bond or dashed line representing a particular configurationthen that stereoisomer is so specified and defined. Following thestandard chemical literature description practice and as used herein, afull wedge bond means above the ring plane, and a dashed wedge bond ordashed line means below the ring plane.

Pharmaceutically acceptable solvates of compound of formula (I) may behydrates or comprising other solvents of crystallization such asalcohols. Pharmaceutically acceptable solvates of compound of formula(I) may be prepared by conventional methods such as dissolving thecompounds of formula (I) in solvents such as water, methanol, ethanoletc., preferably water and recrystallizing by using differentcrystallization techniques.

In the formulae depicted herein, a bond to a substituent and/or a bondthat links a molecular fragment to the remainder of a compound may beshown as intersecting one or more bonds in a ring structure. Thisindicates that the bond may be attached to any one of the atoms thatconstitutes the ring structure, so long as a hydrogen atom couldotherwise be present at that atom. Where no particular substituent(s) isidentified for a particular position in a structure, then hydrogen(s) ispresent at that position.

Reference will now be made in detail to the embodiments of theinvention, one or more examples of which are set forth below. Eachexample is provided by way of explanation of the invention, and not byway of limitation of the invention. In fact, it will be apparent tothose skilled in the art that various modification and variations can bemade in the present invention without departing from the scope or spiritof the invention. For instance, features illustrated or described aspart of one embodiment can be used on another embodiment to yield astill further embodiment. Thus it is intended that the present inventioncover such modifications and variations as come within the scope of theappended claims and their equivalents. Other objects, features, andaspects of the present invention are disclosed in, or are obvious from,the following detailed description. It is to be understood by one ofordinary skill in the art that the present discussion is a descriptionof exemplary embodiments only, and is not to be construed as limitingthe broader aspects of the present application.

Thus in accordance of this application there is provided a series ofsubstituted pyrazolo[1,5-a]pyridine derivatives having the generalformula (I),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein

X¹ is CH or N;

-   -   R¹ represents hydrogen or —(C₁-C₆)alkyl;    -   R² is independently selected from hydrogen, halogen, cyano,        —(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl, -halo(C₁-C₆)alkoxy, phenyl        optionally substituted with 1 to 3 halogens or an optionally        substituted —O-heterocyclyl wherein the optional substituent is        selected from alkyl, —OR^(i) or —C(O)N(R^(i))₂;    -   when X¹ is CH, optionally two R²s present on any two adjacent        carbon atoms combine to form a 5 to 7 membered heterocyclic        ring;    -   R³ is independently selected from halogen, cyano, —OR^(i),        —C(O)N(R^(i))₂ or two R³s together with the carbon atom they are        attached form a (C₃-C₇)cycloalkyl group spiro attached to        pyrrolidine; or two R³ when they are attached to adjacent carbon        atoms form a (C₃-C₇)cycloalkyl ring fused to the pyrrolidine;    -   R^(a) is selected from        -   (i) a group selected from optionally substituted            —(C₁-C₆)alkyl, -hydroxy(C₁-C₆)alkyl or            —(C₁-C₆)alkyl-(C₁-C₆)alkoxy wherein the optional            susbstituent is selected from cyano, halogen or            —(C₆-C₁₂)aryl,        -   (ii) an optionally substituted —(C₃-C₁₀)cycloalkyl wherein            the optional substituent is selected from cyano,            —(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s),        -   (iii) an optionally substituted —(C₆-C₁₂)aryl wherein the            optional substituent is selected from cyano, hydroxyl,            halogen, —(C₁-C₆)alkyl or —R^(r)        -   (iv) an optionally substituted 5 to 10 membered heterocyclyl            wherein the optional substituent is selected from cyano,            hydroxyl, halogen or —(C₁-C₆)alkyl,        -   (v) an optionally substituted 5 to 10 membered heteroaryl            wherein the optional substituent is selected from cyano, oxo            (═O), hydroxyl, halogen, —(C₁-C₆)alkyl, —(C₁-C₆)alkoxy,            —NR^(c)R^(d) or —R^(r),        -   (vi) —NR⁴R⁵,        -   (vii) —(C₁-C₆)alkyl-(C₆-C₁₂)aryl;    -   R^(b) represents hydrogen or halogen;    -   R⁴ is selected from hydrogen, —(C₁-C₆)alkyl,        —(C₃-C₁₀)cycloalkyl, -hydroxy(C₁-C₆)alkyl, -alkoxy(C₁-C₆)alkyl,        -halogen(C₁-C₆)alkyl or —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl;    -   R⁵ is selected from hydrogen or —(C₁-C₆)alkyl or        —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl;    -   Alternatively R⁴ and R⁵ together with the nitrogen atom to which        they are attached may form an optionally substituted 5 to 10        membered heterocyclic ring optionally containing 1-2 additional        heteroatoms or groups selected from —O—, —S—, —N—, —C(═O)—,        —S(═O)— or —S(═O)₂—, wherein the optional substituent is        selected from hydroxyl, —(C₁-C₆)alkyl, —C(═O)—(C₁-C₆)alkyl,        mesyl or COOR^(e);    -   R^(c) and R^(d) are independently selected from hydrogen or        —(C₁-C₆)alkyl;    -   R^(e) is selected from hydrogen or alkyl;    -   R^(i) is hydrogen, —(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl,        —(C₁-C₆)alkyl-(C₁-C₆)alkoxy, —(C₃-C₁₀)cycloalkyl, optionally        substituted —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl wherein the        optional substituent is halogen or —(C₁-C₆)alkyl substituted        with 1 to 3 hydroxy groups;    -   R^(r) is independently selected from a 5 to 10 membered        heterocyclyl or a 5 to 10 membered heteroaryl, wherein optional        substituent is selected from hydroxyl, halogen, —(C₁-C₆)alkyl or        —(C₁-C₆)alkoxy;    -   R^(s) is an optionally substituted —(C₁-C₆)alkyl-(C₆-C₁₀)aryl,        wherein the optional substituent is halogen;    -   m is independently represents 0, 1, 2, 3 or 4; and    -   n is independently represents 0, 1, 2, or 3.

In one embodiment, there is provided a compound of formula (I),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein

-   -   A is

X¹ is CH or N;

-   -   R¹ represents hydrogen or —(C₁-C₆)alkyl;    -   R² is independently selected from hydrogen, halogen, cyano,        —(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl, -halo(C₁-C₆)alkoxy, phenyl        optionally substituted with 1 to 3 halogens or an optionally        substituted —O-heterocyclyl wherein the optional substituent is        selected from alkyl, —OR^(i) or —C(O)N(R^(i))₂;    -   when X¹ is CH, optionally two R²s present on any two adjacent        carbon atoms combine to form a 5 to 7 membered heterocyclic        ring;    -   R³ is independently selected from halogen, cyano, —OR^(i),        —C(O)N(R^(i))₂ or two R³s together with the carbon atom they are        attached form a (C₃-C₇)cycloalkyl group spiro attached to        pyrrolidine; or two R³ when they are attached to adjacent carbon        atoms form a (C₃-C₇)cycloalkyl ring fused to the pyrrolidine;    -   R^(a) is selected from        -   (i) a group selected from optionally substituted            —(C₁-C₆)alkyl, -hydroxy(C₁-C₆)alkyl or            —(C₁-C₆)alkyl-(C₁-C₆)alkoxy wherein the optional            susbstituent is selected from cyano, halogen or            —(C₆-C₁₂)aryl,        -   (ii) an optionally substituted —(C₃-C₁₀)cycloalkyl wherein            the optional substituent is selected from cyano,            —(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s),        -   (iii) an optionally substituted —(C₆-C₁₂)aryl wherein the            optional substituent is selected from cyano, hydroxyl,            halogen, —(C₁-C₆)alkyl or —R^(r)        -   (iv) an optionally substituted 5 to 10 membered heterocyclyl            wherein the optional substituent is selected from cyano,            hydroxyl, halogen or —(C₁-C₆)alkyl,        -   (v) an optionally substituted 5 to 10 membered heteroaryl            wherein the optional substituent is selected from cyano, oxo            (═O), hydroxyl, halogen, —(C₁-C₆)alkyl, —(C₁-C₆)alkoxy,            —NR^(c)R^(d) or —R^(r),        -   (vi) —NR⁴R⁵,        -   (vii) —(C₁-C₆)alkyl-(C₆-C₁₂)aryl;    -   R^(b) represents hydrogen or halogen;    -   R⁴ is selected from hydrogen, —(C₁-C₆)alkyl,        —(C₃-C₁₀)cycloalkyl, -hydroxy(C₁-C₆)alkyl, -alkoxy(C₁-C₆)alkyl,        -halogen(C₁-C₆)alkyl or —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl;    -   R⁵ is selected from hydrogen or —(C₁-C₆)alkyl or        —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl;    -   Alternatively R⁴ and R⁵ together with the nitrogen atom to which        they are attached may form an optionally substituted 5 to 10        membered heterocyclic ring optionally containing 1-2 additional        heteroatoms or groups selected from —O—, —S—, —N—, —C(═O)—,        —S(═O)— or —S(═O)₂—, wherein the optional substituent is        selected from hydroxyl, —(C₁-C₆)alkyl, —C(═O)—(C₁-C₆)alkyl,        mesyl or COOR^(e);    -   R^(c) and R^(d) are independently selected from hydrogen or        —(C₁-C₆)alkyl;    -   R^(e) is selected from hydrogen or alkyl;    -   R^(i) is hydrogen, —(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl,        —(C₁-C₆)alkyl-(C₁-C₆)alkoxy, —(C₃-C₁₀)cycloalkyl, optionally        substituted —(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl wherein the        optional substituent is halogen or —(C₁-C₆)alkyl substituted        with 1 to 3 hydroxy groups;    -   R^(r) is independently selected from a 5 to 10 membered        heterocyclyl or a 5 to 10 membered heteroaryl, wherein optional        substituent is selected from hydroxyl, halogen, —(C₁-C₆)alkyl or        —(C₁-C₆)alkoxy;    -   R^(s) is an optionally substituted —(C₁-C₆)alkyl-(C₆-C₁₀)aryl,        wherein the optional substituent is halogen;    -   m is independently represents 0, 1, 2, 3 or 4; and    -   n is independently represents 0, 1, 2, or 3.

In another embodiment, the compounds of formula (I) are represented ascompounds of formula (Ia),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ib),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ic),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Id),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ie),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (If),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ig),

wherein the values of all the variables are as described for compound offormula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ih),

wherein the values of all the variables are as described for compound offormula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ii),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ij),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ik),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Ikk),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described for compound of formula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Il),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein R³ is fluorine, n is 1 or 2,and the values of all other variables are as described for compound offormula (I).

In another embodiment, compounds of formula (I) are represented ascompounds of formula (Im),

their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein R³ is fluorine, n is 1 or 2,and the values of all other variables are as described for compound offormula (I).

In one embodiment of formula (Ia), R¹ is hydrogen, R^(a) is—(C₁-C₆)alkyl or an optionally substituted —(C₃-C₁₀)cycloalkyl group,wherein the optional substituent independently selected from cyano,—(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s).

In one embodiment of formula (Ia), R¹ is hydrogen, R^(a) is anoptionally substituted —(C₆-C₁₂)aryl, wherein the optional substituentis selected from cyano, hydroxyl, halogen, —(C₁-C₆)alkyl or —R^(r).

In one embodiment of formula (Ia), R¹ is hydrogen, R^(a) is anoptionally substituted 5 to 10 membered heterocyclyl optionallysubstituted with 1 to 3 substituents independently selected from cyano,hydroxyl, halogen or —(C₁-C₆)alkyl.

In one embodiment of formula (Ia), R¹ is hydrogen, R^(a) is —NR⁴R⁵.

In one embodiment of formula (Ia), R^(a) is an optionally substituted 5to 10 membered heteroaryl, wherein the optional substituent is selectedfrom cyano, oxo (═O), hydroxyl, halogen, —(C₁-C₆)alkyl, —(C₁-C₆)alkoxy,—NR^(c)R^(d) or —R^(t).

In another embodiment, the compound of formula (Ia) of the aboveembodiments is defined as compound of formula (Ib).

In certain embodiments of formula (Ib), as defined above, R², in eachoccurrence, independently represents halogen, cyano or haloalkyl; m is 1or 2.

In certain embodiments of formula (Ib), as defined above, R¹ ishydrogen.

In certain embodiment of formula (Ib), R⁴ and R⁵, independentlyrepresents methyl, ethyl or propyl.

In certain embodiment of formula (Ib), R^(a), independently representsmethyl, ethyl, propyl, isopropyl, butyl or tert-butyl.

In one embodiment of formula (Ic), R¹ is hydrogen, R^(a) is—(C₁-C₆)alkyl or optionally substituted —(C₃-C₁₀)cycloalkyl, wherein theoptional substituent is independently selected from selected from cyano,—(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s).

In one embodiment of formula (Ic), R¹ is hydrogen, R^(a) is optionallysubstituted —(C₆-C₁₂)aryl, wherein the optional substituent is selectedfrom cyano, hydroxyl, halogen, —(C₁-C₆)alkyl or —R^(r).

In one embodiment of formula (Ic), R¹ is hydrogen, R^(a) is anoptionally substituted 5 to 10 membered heterocyclyl, wherein theoptional substituent is selected from cyano, hydroxyl, halogen or—(C₁-C₆)alkyl.

In one embodiment of formula (Ic), R¹ is hydrogen, R^(a) is —NR⁴R⁵.

In one embodiment of formula (Ic), R^(a) is an optionally substituted 5to 10 membered heteroaryl, wherein the optional substituent is selectedfrom cyano, oxo (═O), hydroxyl, halogen, —(C₁-C₆)alkyl, —(C₁-C₆)alkoxy,—NR^(c)R^(d) or —R^(t).

In another embodiment, the compound of formula (Ic) of the aboveembodiments is defined as compound of formula (Id).

In certain embodiments of formula (Id), as defined above, R², in eachoccurrence, independently represents halogen, cyano or haloalkyl; m is 1or 2.

In certain embodiments of formula (Id), as defined above, R¹ ishydrogen.

In certain embodiment of formula (Id), R⁴ and R⁵, independentlyrepresents methyl, ethyl or propyl.

In certain embodiment of formula (Id), R^(a), independently representsmethyl, ethyl, propyl, isopropyl, butyl or tert-butyl.

In one embodiment of formula (Ic), R¹ is hydrogen, R^(a) is—(C₁-C₆)alkyl or optionally substituted —(C₃-C₁₀)cycloalkyl, wherein theoptional substituent is independently selected from lected from cyano,—(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s).

In one embodiment of formula (Ic), R¹ is hydrogen, R^(a) is optionallysubstituted —(C₆-C₁₂)aryl, wherein the optional substituent is selectedfrom cyano, hydroxyl, halogen, —(C₁-C₆)alkyl or —R^(r).

In one embodiment of formula (Ie), R¹ is hydrogen, R^(a) is anoptionally substituted 5 to 10 membered heterocyclyl, wherein theoptional substituent is selected from cyano, hydroxyl, halogen or—(C₁-C₆)alkyl.

In one embodiment of formula (Ie), R¹ is hydrogen and R^(a) is —NR⁴R⁵.

In one embodiment of formula (Ie), R^(a) is an optionally substituted 5to 10 membered heteroaryl, wherein the optional substitutent is selectedfrom cyano, oxo (═O), hydroxyl, halogen, —(C₁-C₆)alkyl, —(C₁-C₆)alkoxy,—NR^(c)R^(d) or —R^(t).

In another embodiment, the compound of formula (Ie) of the aboveembodiments is defined as compound of formula (If).

In certain embodiments of formula (If), as defined above, R², in eachoccurrence, independently represents halogen, cyano or haloalkyl; m is 1or 2.

In certain embodiments of formula (If), as defined above, R¹ ishydrogen.

In certain embodiment of formula (If), R⁴ and R⁵, independentlyrepresents methyl, ethyl or propyl.

In certain embodiment of formula (If), R^(a), independently representsmethyl, ethyl, propyl, isopropyl, butyl or tert-butyl.

In another embodiment, the compound of formula (Ig) of the aboveembodiment is defined as compound of formula (Ih).

In certain embodiments of formula (Ih), as defined above, R², in eachoccurrence, independently represents halogen, cyano or haloalkyl and mis 1 or 2.

In certain embodiments of formula (Ih), as defined above, R¹ ishydrogen.

In certain embodiment of formula (Ih), R⁴ and R⁵, independentlyrepresents methyl, ethyl or propyl.

In another embodiment, the compound of formula (Ii) of the aboveembodiments is defined as compound of formula (Ij).

In certain embodiments of formula (Ij), as defined above, R², in eachoccurrence, independently represents halogen, cyano or haloalkyl and mis 1 or 2.

In certain embodiments of formula (Ij), as defined above, R¹ ishydrogen.

In certain embodiment of formula (Ij), R⁴ and R⁵, independentlyrepresents methyl, ethyl or propyl.

In certain embodiments of formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ii), (Ij) and (Ik), R^(b) is hydrogen.

In certain embodiments of formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ii), (Ij) and (Ik), R^(b) is fluorine.

In certain embodiments of formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ii), (Ij) and (Ik), wherein R², in each occurrence,independenty represents fluorine.

In certain embodiments of formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ii), (Ij) and (Ik), wherein R³, in each occurrence,independenty represents fluorine.

The compounds of formula (I) can also exist in the form ofpharmaceutically acceptable salts, pharmaceutically acceptable solvatesor stereoisomers thereof

In another embodiment, the present application provides compounds offormula (9i),

or its stereoisomers thereof, wherein the values of all the variablesare as described for compound of formula (I).

In another embodiment, the present application provides compounds offormula (9ii),

or its stereoisomers thereof, wherein A represents

and values of all other variables are as described for compound offormula (I).

In another embodiment, the present application provides compounds offormula (10i),

or its stereoisomers thereof, wherein the values of all the variablesare as described for compound of formula (I).

In another embodiment, the present application provides compounds offormula (10ii),

or its stereoisomers thereof, wherein A represents

and values of all other variables are as described for compound offormula (I).

In another embodiment, the present application provides compounds offormula (13),

or its stereoisomers thereof, wherein the values of all variables are asdescribed for compound of formula (I).

The present application relates to the compounds of formula (I), whichare inhibitrs of TrkA, TrkB and/or TrkC kinase activity, for thetreatment or prevention of diseases or conditions or disordersassociated with TrkA, TrkB and/or TrkC kinase activity.

One embodiment of the present application further provides methods oftreating or preventing conditions, diseases and/or disorders associatedTrkA, TrkB and/or TrkC kinase activity, wherein the method includesadministration of a therapeutically effective amount of a compoundformula (I), to a patient in need thereof.

One embodiment of the present application provides conditions. diseasesand/or disorders treatable or preventable by inhibition of Trk kinaseactivity, such as pain, inflammation, cancer, restenosis,atherosclerosis, psoriasis, thrombosis, psoriatic arthritis, rheumatoidarthritis, inflammatory bowel disease, ulcerative colitis, Crohn'sdisease, fibrosis, neurodegenerative; a disease, disorder or injuryrelating to dysmyelination or demyelination or infectious diseases suchas Trypanosoma cruzi infection by administering a therapeuticallyeffective amount of compound of formula (I), to a patient in needthereof.

One embodiment of the present application further provides methods oftreating or preventing conditions, diseases and/or disorders associatedTrkA, wherein the method includes administration of a therapeuticallyeffective amount of a compound formula (I), to a patient in needthereof.

In another embodiment, there is provided a method of treating orpreventing pain or pain disorder in a patient in need of such atreatment comprising the administration of a therapeutically effectiveamount of the compound of formula (I), to said patient.

In another embodiment, pain includes chronic and acute pain but is notlimited to, pain related to cancer, surgery, bone fracture, skeletalpain caused by tumor metastasis, osteoarthritis, psoriatic arthritis,rheumatoid arthritis, interstitial cystitits, chronic pancreatitis,visceral pain, inflammatory pain, migraine, chronic lower back pain,bladder pain syndrome and neuropathic pain.

In one embodiment, there is provided a method of binding TrkA protein ina patient in need of such a treatment comprising the administration of atherapeutically effective amount of the compound of formula (I) to saidpatient.

The present application further relates to use of compound of formula(I) for treating or preventing conditions, diseases and/or disordersassociated with abnormal or deregulated Trk kinase activity.

One aspect of the present application provides use of compound offormula (I) for treating or preventing conditions, diseases and/ordisorders associated with abnormal or deregulated TrkA kinase activity,in a patient in need thereof.

In another embodiment, there is provided an use of the compound forformula (I) for treating or preventing pain or pain disorder in apatient in need of such a treatment, comprising the administration of atherapeutically effective amount of the compound of formula (I), to saidpatient.

In another embodiment of the present application, pain includes chronicand acute pain but is not limited to, pain related to cancer, surgery,bone fracture, skeletal pain caused by tumor metastasis, osteoarthritis,visceral pain, inflammatory pain and neuropathic pain.

In yet another embodiment, the compounds of the present application maybe useful for the pain disorders include neuropathic pain (such aspostherpetic neuralgia, nerve injury, the “dynias”, e.g., vulvodynia,phantom limb pain, root avulsions, painful diabetic neuropathy, painfultraumatic mononeuropathy, painful polyneuropathy); central painsyndromes (potentially caused by virtually any lesion at any level ofthe nervous system); postsurgical pain syndromes (eg, postmastectomysyndrome, postthoracotomy syndrome, stump pain); bone and joint pain(osteoarthritis), repetitive motion pain, denial pain, cancer pain,myofascial pain (muscular injury, fibromyalgia); perioperative pain(general surgery, gynecological), chronic pain, dysmenorrhea, as well aspain associated with angina, and inflammatory pain of varied origins(e.g. osteoarthritis, rheumatoid arthritis, rheumatic disease,teno-synovitis and gout), headache, migraine and cluster headache,headache, primary hyperalgesia, secondary hyperalgesia, primaryallodynia, secondary allodynia, or other pain caused by centralsensitization.

In another embodiment of the above aspect, there is provided a method oftreating or preventing pain which comprises administering to saidsubject a pharmaceutical composition comprising an effective amount of acompound of formula (I).

Another embodiment of the application provides the use of suchcompositions in the treatment and/or prevention of diseases associatedwith inhibition of TrkA, such as pain, cancer, restenosis,atherosclerosis, psoriasis, thrombosis, neurodegenerative disease, adisease, disorder, or injury relating to dysmyelination or demyelinationor certain infectious diseases such as Trypanosoma crurzi infection.

In another embodiment, the compounds of formula (I) are useful intreating or preventing neurodegenerative disease.

In one embodiment, neurodegenerative disease is Parkinson's disease orAlzheimer's disease.

In another aspect, the present application provides a method of treatingor preventing neurodegenerative disease.

In one embodiment, neurodegenerative disease, as described above, isParkinson's disease or Alzheimer's disease.

In another embodiment, the present application provides method oftreating or preventing certain infectious diseases, for exampleTrypanosoma cruzi infection, by administering effective amount ofcompound of formula (I) to a patient in need thereof.

In another embodiment, the present application provides method oftreating or preventing Trypanosoma cruzi infection by administeringeffective amount of compound of formula (I), to a patient in needthereof.

In another embodiment, certain compounds of formula (I) posseses Ratliver microsome (RLM) stability (half life in minutes) >30,specifically >60, more specifically >80, still further more specifically>90.

In another embodiment, certain compounds of formula (I) posseses Humanliver microsome (HLM) stability (half life in minutes) >30,specifically >60, more specifically >80, still further more specifically>90.

In one embodiment of the present application, there is provided apharmaceutical composition comprising a therapeutically effective amountof one or more compounds of formula (I) and pharmaceutically acceptablecarrier.

Another embodiment of the present application provides a method ofadministering TrkA inhibitors in a subject (i.e., a patient), whichcomprises administering to said subject (i.e., a patient) apharmaceutical composition comprising a therapeutically effective amountof a compound of formula (I). As used herein the term “subject” and“patient” can be the same and can be used interchangeably.

In another embodiment, there is provided a method of inhibiting TrkAcomprising administering to said subject a pharmaceutical compositioncomprising an effective amount of a compound of formula (I).

In an embodiment, specific compounds of formula (I) without anylimitation are enumerated below (List-1):

-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo    [1,5-a] pyridine-3-carboxamide,-   (R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)    phenyl) sulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,-   (R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-methyl    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,    5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)    sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(cyclohexylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)—N-(cyclopentylsulfonyl)-5-(2-(2,    5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1,    5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-4-yl) sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-5-yl) sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl)pyrazolo[1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl)pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl)pyrazolo [1,    5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((2,4-dimethylthiazol-5-yl) sulfonyl)pyrazolo [1,    5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl) sulfonyl)pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl)pyrazolo [1,    5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl)    sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   5-((R)-2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   5-((R)-2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl) pyrazolo [1,    5-a] pyridine-3-carboxamide,-   (R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl)pyrazolo [1,    5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2,    5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)—N-(cyclobutylsulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)    sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl)    pyrrolidin-1-yl)pyrazolo [1, 5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Isomer-I),-   N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Isomer-II),-   N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Isomer-I),-   N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Isomer-II),-   (R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (S)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)-4,    4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)-4,    4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)    pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy)    phenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy)    phenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   5-((R)-2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)    sulfonyl)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1,    5-a] pyridine-3-carboxamide,-   5-((R)-2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methyl    cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethyl    sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methyl    sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethyl    sulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)    sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methyl    sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)    sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II),-   N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II),-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II),-   N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoyl    pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-2);-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methyl    sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-bis(cyclopropylmethyl)    sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II),-   N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]    pyridine-3-carboxamide (Racemic mixture);-   (R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropyl    sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)    oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   Sodium    (tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo    [1,5-a] pyridine-3-carbonyl)amide,-   Sodium    (R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium    (tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium (R)-(5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)    (N,N-dimethylsulfamoyl)amide,-   Sodium    (tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo    [1,5-a]pyridine-3-carbonyl)amide,-   Sodium (R)-(5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,-   Sodium    (tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo    [1,5-a]pyridine-3-carbonyl)amide,-   Sodium    (5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,-   Sodium    (tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium    (R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo    [1,5-a]pyridine-3-carbonyl)amide,-   Sodium    (N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium (R)-(5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide,-   Sodium    (4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carbonyl) (isopropylsulfonyl)amide,-   Sodium    (5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,    or-   Sodium (R)-(5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide;

or a pharmaceutically acceptable salt thereof, a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo    [1,5-a] pyridine-3-carboxamide,-   5-((R)-2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-methylpyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((4-morpholinophenyl) sulfonyl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   5-((R)-2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)    (piperidin-1-ylsulfonyl)amide, or-   Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)    (o-tolylsulfonyl)amide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   (R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]    pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo    [1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)    pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy)    phenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy)    phenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Racemic mixture);-   (R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]    pyridine-3-carbonyl)amide, or-   Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   (R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(cyclohexyl sulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(cyclopentyl sulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-(cyclobutylsulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,    5-a]pyridine-3-carboxamide, or-   Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.-   In one embodiment, compounds of formula (I) are represented as-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-4-yl) sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-5-yl) sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((2,4-dimethylthiazol-5-yl) sulfonyl) pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl)    sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,-   5-((R)-2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl) pyrazolo [1,    5-a] pyridine-3-carboxamide,-   (R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl) pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide;-   (R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2,    5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)    sulfonyl)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1,    5-a] pyridine-3-carboxamide, or-   5-((R)-2-(3,5-difluorophenyl)    pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)    sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]    pyridine-3-carboxamide,-   (R)-5-(2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo    [1, 5-a] pyridine-3-carboxamide,-   5-((R)-2-(2, 5-difluorophenyl)    pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl)    pyrazolo [1, 5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)    sulfonyl)pyrazolo [1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,    or-   5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)    sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   (R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methyl    cyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo    [1,5-a]pyridine-3-carboxamide,-   4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   Sodium(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)    (isopropylsulfonyl)amide,-   Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,-   Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,-   Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,    or-   Sodium    (tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N—(N,    N-dimethylsulfamoyl)pyrazolo[1,5-a] pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)    pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methyl    sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   (R)—N—(N,N-bis(cyclopropylmethyl)    sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,-   Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,-   Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)    phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, or-   Sodium (R)-(5-(2-(2,5-difluorophenyl)    pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide;    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In one embodiment, compounds of formula (I) are represented as

-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II),-   N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II),-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-I),-   N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-II), or-   N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide    (Diastereomer-2);    or a pharmaceutically acceptable salt thereof, a pharmaceutically    acceptable solvate thereof    or a stereoisomer thereof.

In another embodiment, there is provided a method of treating orpreventing pain or pain disorder in a patient in need of such atreatment comprising the administration of a therapeutically effectiveamount of the compound of formula (I) enlisted in List-1, or astereoisomer thereof or a pharmaceutically acceptable salt thereof tosaid patient.

The present application further relates to methods of treating a patientfor diseases or disorders in which the nerve growth factor (NGF)receptor are involved, in particular TrkA, such as such as pain, cancer,restenosis, atherosclerosis, psoriasis, thrombosis, or a disease,disorder, or injury relating to dysmyelination or demyelination, byadministering a therapeutically effective amount of compound of formula(I), as enlisted in List-1, to said patient.

In another embodiment, there is provided a method of treating orpreventing pain or pain disorder in a patient in need of such atreatment comprising the administration of a therapeutically effectiveamount of the compound of formula (I), as enlisted in List-1, to saidpatient.

In another embodiment, pain includes chronic and acute pain but is notlimited to, pain related to cancer, surgery, bone fracture, skeletalpain caused by tumor metastasis, osteoarthritis, visceral pain,inflammatory pain and neuropathic pain.

In one embodiment, there is provided a method of binding NGF receptorTrkA protein in a patient in need of such a treatment comprising theadministration of a therapeutically effective amount of the compound offormula (I), as enlisted in List-1, to said patient.

The present application further relates to use of compound offormulation (I) for treating a patient for diseases or disorders inwhich the NGF receptor are involved, in particular TrkA, such as such aspain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or adisease, disorder, or injury relating to dysmyelination ordemyelination, by administering a therapeutically effective amount ofcompound of formula (I), as enlisted in List-1, to said patient.

In another embodiment, there is provided an use of the compound forformula (I) for treating or preventing pain or pain disorder in apatient in need of such a treatment, comprising the administration of atherapeutically effective amount of the compound of formula (I), asenlisted in List-1, to said patient.

In another embodiment, pain includes chronic and acute pain but is notlimited to, pain related to cancer, surgery, bone fracture, skeletalpain caused by tumor metastasis, osteoarthritis, visceral pain,inflammatory pain and neuropathic pain.

In another embodiment of the above aspect, there is provided a method oftreating or preventing pain which comprises administering to saidsubject a pharmaceutical composition comprising an effective amount of acompound of formula (I), as enlisted in List-1.

Another embodiment of the application provides the use of suchcompositions in the treatment or prevention of diseases associated withinhibiting NGF receptor TrkA, such as pain, cancer, restenosis,atherosclerosis, psoriasis, thrombosis, or a disease, disorder, orinjury relating to dysmyelination or demyelination.

One embodiment of the present application provides intermediates as

-   2-(7-fluoro-2, 3-dihydrobenzo[b] [1, 4]dioxin-5-yl)pyrrolidine,-   Ethyl 5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)    pyrrolidin-1-yl) pyrazolo[1, 5-a]pyridine-3-carboxylate (Isomer-I),-   5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxylic acid    (Isomer-I)-   Ethyl 5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)    pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxylate (Isomer-II)-   5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)    pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxylic acid    (Isomer-II)

The pharmaceutical composition of a compound of formula (I) may beadministered enterally and/or parenterally. Parenteral administrationincludes subcutaneous, intramuscular, intradermal, intramammary,intravenous, and other administrative methods known in the art. Enteraladministration includes solution, tablets, sustained release capsules,enteric coated capsules, syrups, beverages, foods, and other nutritionalsupplements. When administered, the present pharmaceutical compositionsmay be at or near body temperature. In some embodiments, the presentpharmaceutical compositions may be below body temperatures. In otherembodiments, the present pharmaceutical compositions may be above bodytemperatures.

The compounds of the present invention may be administered in a widevariety of different dosage forms. For example, they may be combinedwith various pharmaceutically acceptable inert carriers in the form of,but not limited to, tablets, capsules, lozenges, troches, hard candies,powders, sprays, creams, salves, suppositories, jellies, gels, pastes,lotions, ointments, aqueous suspensions, injectable solutions, elixirs,syrups, and the like. Such carriers may include solid diluents orfillers, sterile aqueous media, and various nontoxic organic solvents,etc. Moreover, oral pharmaceutical compositions may be sweetened and/orflavored. In general, the compounds of the invention may be present insuch dosage forms at concentration levels ranging from about 0.1% toabout 90% by weight.

In general, compounds of the present invention for treatment may beadministered to a subject in a suitable effective dose in the range offrom about 0.01 to about 100 mg per kilogram of body weight of recipientper day, in some embodiments, in the range of from about 0.5 to about 50mg per kilogram body weight of recipient per day, in still otherembodiments, in the range of from about 0.1 to about 20 mg per kilogrambody weight of recipient per day. The exemplary dose may be suitablyadministered once daily, or several sub-doses, e.g. 2 to 5 sub-doses,may be administered at appropriate intervals through the day, or onother appropriate schedules.

An embodiment of the present invention provides the preparation ofcompounds of formula (I) according to the procedures of the followingexamples, using appropriate materials. Those skilled in the art willunderstand that known variations of the conditions and processes of thefollowing preparative procedures can be used to prepare these compounds.Moreover, by utilizing the procedures described in detail, one ofordinary skill in the art can prepare additional compounds of thepresent invention claimed herein. All temperatures are in degreesCelsius (° C.) unless otherwise noted.

The following acronyms, abbreviations, terms and definitions have beenused throughout the reaction scheme and experimental section.

ACN (Acetonitrile), BINAP (2,2′-bis(diphenylphosphino)-1,1′-binaphthyl),CDCl₃ (Deuterated chloroform), CD₃OD (Deuterated methanol), Cs₂CO₃(Caesium Carbonate) DCM (Dichloromethane), DIPEA[(N,N-diisopropylethylamine) (Hünig's base)], DMF(N,N-dimethylformamide), DMSO (Dimethyl sulfoxide), DMAP (Dimethyl aminopyridine), EtOH (Ethanol), EtOAc (Ethyl acetate), Et₃N (Triethylamine),EDCl (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, HOBt(1-hydroxybenzotriazole), HCl (hydrochloric acid), HATU[O-(-7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluroniumhexafluorophosphate], MeOH (Methanol), LiHMDS (Lithiumbis(trimethylsilyl)amide), LiOH (Lithium hydroxide), K₂CO₃ (PotassiumCarbonate), KOBu_(t) (Potassium tert-butoxide), Pd (Palladium), Pd(OAc)₂(Palladium (II) acetate), Pd₂(dba)₃(Tris(dibenzylideneacetone)dipalladium(0)), POCl₃ (Phosphorusoxychloride), NaHCO₃ (Sodium Bicarbonate), NaOH (Sodium hydroxide),Na₂SO₄ (Sodium Sulfate), NaBH₄ (Sodium borohydride), NH₄Cl (Ammoniumchloride), TFA (Trifluoroacetic acid), THF (Tetrahydrofuran), H₂O(Water).

Another embodiment of the present invention provides a process for thepreparation of compounds of formulae (Ii)-(Iix) represent respectively asub-group of a compound of formula (I), wherein all symbols/variablesare as defined earlier unless otherwise stated. The process isrepresented by Scheme-1:

Compound of formula (3) obtained from compound (1) (prepared accordingto the procedure described in J. Org. Chem. 2003, 68, 7119-7122) and (2)was reacted with compound (4) to obtain of formula (5) where R^(b) is asdefined as before.

A compound of formula (6) can be obtained by reacting a compound offormula (5) with trifluoroacetic acid in dichloromethane at roomtemperature.

A compound of formula (7) was obtained from compound of formula (6) bystandard Sandmeyer reaction protocol.

A compound of formula (9) was obtained from compound of formula (7) byreaction with compound of formula (8) in the presence of Pd₂dba₃, BINAP,Et₃N and Cs₂CO₃, in a solvent such as 1,4-dioxane and the like at atemperature of about 60 to about 80° C. for about 12 to about 16 h whereA is as defined before A compound of formula (9) to formula (10) can beconverted using reagents such as 3M LiOH solution, 5N NaOH solution andthe like in presence of a suitable solvent such as THF, THF-MeOH and thelike.

A compound of formula (10) to formula (I) can be converted by usingsuitable reagents such as HATU, DIPEA or HATU, HOBt, DIPEA or EDCI,HOBt, DIPEA or EDCI, DMAP or EDCI, HOBt, NaH and the like in presence ofa suitable solvent such as DMF, DCM and the like at a temperature ofabout 20 to about 65° C. for about 15 to about 18 h.

Another embodiment of the present invention provides a process for thepreparation of compounds of formulae (10i), (11i) and (1i), wherein allsymbols/variables are as defined earlier unless otherwise stated. Theprocess is represented by Scheme-2:

A compound of formula (10i) can be obtained from compound of formula(9i) by reacting with hydroxyl containing compounds like R^(i)OH whereRi is defined as before under suitable conditions.

A compound of formula (10i) can be converted to the compound of formula(11i) and subsequently to compound of formula (1i) using conditions asmentioned under Scheme-1.

Another embodiment of the present invention provides a process for thepreparation of compounds of formulae (10ii), (11ii), (12i) and (1iii),wherein all symbols/variables are as defined earlier unless otherwisestated. The process is represented by Scheme-3:

A compound of formula (10ii) can be obtained from compound of formula(9ii) by reacting with BBr₃ in a suitable solvent like dichloromethane.

A compound of formula (10ii) can be converted to the compound of formula(11ii) using suitable reaction conditions known in the art.

A compound of formula (11ii) can be converted to the compound of formula(12ii) and subsequently to compound of formula (1ii) using conditions asmentioned under Scheme-1.

Another embodiment of the present invention provides a process for thepreparation of compounds of formula (13), wherein all symbols/variablesare as defined earlier unless otherwise stated. The process isrepresented by Scheme-4:

A compound of formula (13ii) can be obtained from compound of formula(13i) by nitration in presence of fuming nitric acid/acetic acid or asimilar nitrating reagent.

Nitration of the compounds (13ii) on Dakin oxidation resulted compoundof formula (13iii), which can be cyclized to compound (13iv) by reactingwith a dihalo alkyl in presence of a suitable base and solvent.

Compound of formula (13v) can be obtained by reduction of (13iv) inpresence of a suitable reducing agent, which can then be converted to acompound of formula (13vi) by Sandmeyer reaction with a suitable copperhalide.

Compound of formula (13vi) can be converted to a compound of formula(13vii) by magnesium metal mediated reaction with Boc protectedpyrrolidin-2-one derivatives.

Compound of formula (13vii) on TFA de-protection followed by NaBH₄ or asuitable reducing agent mediated reduction afforded compound of formula(13).

As used in the examples and preparations that follow, the terms usedtherein shall have the meanings indicated: “g” or “gm” refers to grams,“mg” refers to milligrams, “g” refers to micrograms, “mol” refers tomoles, “mmol” refers to millimoles, “L” refers to liters, “mL” or “ml”refers to milliliters, “μL” refers to microliters, “mp” or “m.p.” refersto melting point, “mm of Hg” refers to pressure in millimeters ofmercury, “cm” refers to centimeters, “nm” refers to nanometers, “conc.”refers to concentrated, “M” refers to molar, “mM” refers to millimolar,“μM” refers to micromolar, “nM” refers to nanomolar, “TLC” refers tothin layer chromatography, “HPLC” refers to high performance liquidchromatography, “anhyd” refers to anhydrous; “aq” refers to aqueous;“min” refers to minute; “mins” refers to minutes; “h” or “hr” refers tohour; “d” refers to day; “atm” refers to atmosphere; “sat.” refers tosaturated; “s” refers to singlet, “d” refers to doublet; “t” refers totriplet; “q” refers to quartet; “m” refers to multiplet; “dd” refers to“doublet of doublets”; “br” refers to broad; “bs” refers to broadsinglet, “LC” refers to liquid chromatograph; “MS” refers to massspectroscopy; “ESI” refers to electrospray ionization; “CI” refers tochemical ionization; “RT” refers to retention time; “M” refers tomolecular ion; “NMR” refers to nuclear magnetic resonance spectroscopy;“MHz” refers to megahertz.

EXAMPLES

Although the invention has been illustrated by certain of the precedingexamples, it is not to be construed as being limited thereby; butrather, the invention encompasses the generic area as hereinbeforedisclosed. Various modifications and embodiments can be made withoutdeparting from the spirit and scope thereof.

Synthesis of Intermediates Int-6: (R)-2-(2,5-difluorophenyl)pyrrolidinehydrochloride

Int-1: 4-chloro-N-methoxy-N-methylbutanamide

Pyridine (101.28 g, 106.6 mL 1281.79 mmol) was added to a solution ofN,O-dimethylhydroxylamine hydrochloride (50 g, 512.72 mmol) in DCM (800mL) at 0° C. and stirring was continued for 15 min.Chlorobutyrylchloride (72.29 g, 512.72 mmol) was then added to thismixture and was stirred continuously at 0° C. for 2 h. The reactionmixture was diluted with DCM and the organic layer was washed with waterfollowed by brine. The organic layer was separated; dried over anhydroussodium sulphate and concentrated under reduced pressure to afford 79 gof the title compound as a pale brown liquid.

MS (ESI): m/z 166.1 (M+H)

Int-2: 4-chloro-1-(2,5-difluorophenyl)butan-1-one

2-Bromo-1,4-difluorobenzene (53.6 g, 277.74 mmol) in THF cooled to −50°C. was added to isopropyl magnesium chloride (2M in THF)(133 mL, 266mmol). The reaction mixture thus obtained was warmed to 0° C. andstirred for 1 h. The reaction mixture was cooled again to −50° C.4-chloro-N-methoxy-N-methylbutanamide (40 g, 241.52 mmol) in THF (200mL) was added dropwise to this reaction mixture with stirring and thestirring was continued at 0° C. for 1 h. The reaction mixture wasquenched with saturated aqueous NH₄Cl solution, extracted withethylacetate. The organic layer collected was washed with water (500 mL)and then with brine solution, dried over anhydrous sodium sulfate andconcentrated under reduced pressure to afford a crude liquid residue.The residue thus obtained was purified by column chromatography (using60-120 silica gel and 5% EtOAc in Hexane as eluent) to afford 35 g ofthe title compound as a colourless liquid.

¹H NMR (300 MHz, CDCl₃) δ ppm 7.6-7.53 (1H, m), 7.26-7.09 (2H, m), 3.7(2H, t) 3.22-3.14 (2H, m), 2.28-2.16 (2H, m).

Int-3: (S, E)-N-(4-chloro-1-(2, 5-difluorophenyl)butylidene)-2-methylpropane-2-sulfinamide

Titanium (IV) ethoxide (54.77 g, 240.13 mmol) was added to a solution of4-chloro-1-(2,5-difluorophenyl)butan-1-one (35 g, 160.09 mmol) and(S)-2-methylpropane-2-sulfinamide (29.1 g, 240.13 mmol) in THF (400 mL)with stirring. The mixture was stirred continuously at 70° C. for 16 h.Reaction mixture was then cooled to a temperature of 20-35° C., quenchedwith saturated aqueous NH₄Cl solution, diluted with ethylacetate andfiltered. The filtrate was washed with water followed by brine solution.The organic layer was separated, dried over anhydrous sodium sulfate andconcentrated under reduced pressure to afford 44.5 g of the titlecompound as a colourless liquid.

MS (ESI): m/z 322.3 (M+H)

Int-4: (R)-1-((S)-tert-butylsulfinyl)-2-(2, 5-difluorophenyl)pyrrolidine and Int-5: (S)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl) pyrrolidine

(S,E)-N-(4-chloro-1-(2,5-difluorophenyl)butylidene)-2-methylpropane-2-sulfinamide(44 g, 136.72 mmol) in THF (500 mL) was cooled to −78° C. and to whichwas added cold (−78° C.) Lithium triethylborohydride (1M in THF) (17.38g, 165 mL, and 134.67 mmol) dropwise and stirring was continued at −78°C. for 3 h. LiHMDS (1M in THF) (25.26 g, 150 mL, 150 mmol) was thenadded and stirring was continued at −78° C. to 0° C. for 2 h. Theresultant reaction mixture was quenched with saturated NH₄Cl solution,diluted with ethylacetate. The ethylacetate layer separated was washedwith water followed by brine solution, dried over anhydrous sodiumsulphate and concentrated under reduce pressure to afford the cruderesidue. The residue thus obtained was purified by column chromatographytwice (using initially with 60-120 silicagel and 15% EtOAC in Hexane aseluent and again with 230-400 silicagel and 12-14% EtOAc in Hexane aseluent) to afford 14.5 g of the title compound(R)-1-((S)-tert-butylsulfinyl)-2-(2, 5-difluorophenyl) pyrrolidine as apale brown liquid.

¹H NMR (300 MHz, CDCl₃) δ ppm 7.1-6.85 (3H, m), 5.0 (1H, t) 3.93-3.85(1H, m), 3.02-2.94 (1H, m), 2.32-2.2 (1H, m), 2.0-1.72 (3H, m), 1.16(9H, s)

and 4 g of the title compound (S)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl) pyrrolidine.

H NMR (300 MHz, CDCl₃) ¹H NMR (300 MHz, CDCl₃) δ ppm 7.1-6.8 (3H, m),5.42-5.2 (1H, d, J=7.5 Hz), 2.3-2.05 (1H, m), 2.0-1.65 (4H, m), 1.1 (9H,s).

Int-6: (R)-2-(2,5-difluorophenyl) pyrrolidine hydrochloride

4M HCl solution (in Dioxane) (75 mL) was added to stirred solution of(R)-1-((S)-tert-butylsulfinyl)-2-(2, 5-difluorophenyl) pyrrolidine (15g, 52.19 mmol) in Dioxane (25 mL) and stirring was continued at 20-35°C. for 4 h. After which the reaction mixture was concentrated underreduced pressure to afford the crude product. The crude product waspurified by washing with diethyl ether to afford 7.5 g of the titlecompound as a white solid.

MS (ESI): m/z 184 (M+H)

Int-10: 2-(2,5-difluorophenyl)pyrrolidine

Int-7: tert-butyl 2-oxopyrrolidine-1-carboxylate

Di-tert-butyldicarbonate (154 g, 154 mL, 704 mmol) was added to solutionof 2-Pyrrolidinone (50 g, 587 mmol) and DMAP (36 g, 293.7 mmol) inacetonitrile (500 mL) at 0-5° C. and stirring was continued at 20-35° C.for 2 h. Reaction mixture was concentrated under reduced pressure toafford the residue, which was diluted with EtOAc, washed it with water,dried over anhydrous sodium sulphate and concentrated under reducedpressure to afford 73 g of the title compound.

Int-8: tert-butyl5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

2.0 M Isopropyl magnesium chloride solution in THF (163 mL, 324.3 mmol)was added to a solution of 2-bromo-1,4-difluorobenzene (62.5 g, 324.3mmol) in THF (350 mL) at −40° C. and stirring was continued at 5° C. for1 h. tert-Butyl 2-oxopyrrolidine-1-carboxylate (Step-1)(73 g, 392 mmol)in THF (150 mL) was added dropwise to above reaction mixture at −40° C.and stirring was continued at 10° C. for 2 h. Reaction mixture wasquenched with saturated NH₄Cl solution, extracted with EtOAc, dried overanhydrous sodium sulphate and concentrated under reduced pressure toafford 76 g of the title compound.

Int-9: 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

TFA (108 g, 940 mmol) was added to a solution of tert-butyl5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate (53 g, 188mmol) in DCM (300 mL) at 0° C. and stirring was continued at 20-35° C.for 2 h. The reaction mixture was concentrated under reduced pressure toafford the crude, which was diluted with EtOAc, washed with saturatedNaHCO₃ solution, dried over anhydrous sodium sulphate to afford 28.5 gof the title compound.

MS (ESI): m/z 181.9 (M+H)

Int-10: 2-(2,5-difluorophenyl)pyrrolidine

NaBH₄(12 g, 314.9 mmol) was added to a solution of5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in amixture of MeOH:H₂O (4:1, 250 mL) and stirring was continued at 25-35°C. for 2 h. The reaction mixture was quenched with 1N aqueous HClsolution and basified with 2N aqueous NaOH solution, extracted with DCM,dried over anhydrous sodium sulphate and concentrated under reducedpressure to afford 23 g of the title compound.

MS (ESI): m/z 184 (M+H)

Synthesis of ethyl 5-bromo-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate(Int-14)

Int-11:1-amino-4-((tert-butoxycarbonyl)amino)-3-fluoropyridin-1-ium-2,4-dinitrophenolate

A solution of tert-butyl (3-fluoropyridin-4-yl)carbamate (25.0 g, 125mmol) in MeCN (200 ml), was added O-(2,4-dinitrophenyl) hydroxylamine(26.64 g, 125 mmol) in MeCN (200 ml), drop wise over 30 min at RT,reaction mass was stirred at 40° C. for 12 hrs, reaction mass wasconcentrated at temperature below 40° C. under reduced pressure toafford Int-11 (50 g) which was used in the next step without furtherpurification.

Int-12: Ethyl5-((tert-butoxycarbonyl)amino)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate

K₂CO₃ (36.96 g, 267 mmol) was added to a solution of1-amino-4-((tert-butoxycarbonyl)amino)-3-fluoropyridin-1-ium2,4-dinitrophenolate (50 g, 121 mmol) in THF (500 mL) at 28° C. andcontinued stirring at same temperature for 30 min. Ethyl propiolate(14.3 g, 145 mmol) was added to above solution and stirring wascontinued at 28° C. for 16 hr. Reaction mixture was filtered to removethe salt, filtrate collected was diluted with EtOAc washed it with waterfollowed by brine, dried over anhydrous sodium sulphate and concentratedunder reduced pressure to afford crude. The crude obtained was purifiedby column purification (using 60-120 silicagel and 10% EtOAc in Hexaneas eluant) to afford the title compound.

MS m/z 323.9 (M+H)

Int-13: 3-(ethoxycarbonyl)-4-fluoropyrazolo[1,5-a]pyridin-5-aminium2,2,2-trifluoroacetate

To a solution of ethyl5-((tert-butoxycarbonyl)amino)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate(7 g, 21 mmol) in DCM (60 mL), TFA (12 g, 108 mmol) was added at 0-5° C.drop wise over a period of 30 min, then stirred at room temperature for2 hrs, reaction mass was concentrated at temperature below 40° C. underreduced pressure to afford the title compound (7 g) which was used inthe next step without further purification, MS m/z 223.2 (M+)

Int-14: Ethyl 5-bromo-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate

NaNO₂ (2.26 g, 32.89 mmol) in water (7 mL) was added dropwise at 0° C.to a solution of3-(ethoxycarbonyl)-4-fluoropyrazolo[1,5-a]pyridin-5-aminium2,2,2-trifluoroacetate (7 g, 97.5 mmol) in aq. 47% HBr (56 mL) andcontinued stirring at same temperature for 30 min. CuBr (6.29 g, 44mmol) in aq. 47% HBr (56 mL) was added dropwise to above solution at 0°C. and stirring was continued at 28° C. for 1 hr. Reaction mixture wasquenched with ice water, extracted into EtOAc, washed it with waterfollowed by brine, dried over anhydrous sodium sulphate and concentratedunder reduced pressure to afford crude. The crude obtained was purifiedby column purification (using 60-120 silicagel and 5% EtOAc in Hexane aseluant) to afford ethyl5-bromo-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate. NMR (300 MHz,DMSO-d₆) δ 9.45-9.43 (d, 1H), 8.51 (s, 1H), 8.33-8.30 (d, 1H), 4.35-4.28(m, 2H), 1.36-1.31 (t, 3H).

Int-15: 2-methylpropane-2-sulfonamide

Ammonia gas was purged into t-butylsulfonyl chloride (500 mg, 3.2 mmol)in THF (5 mL) at −50° C. for 15 minutes and stirring was continued at20-35° C. for 16 h. The solid precipitate obtained was filtered; thefiltrate collected was concentrated under reduced pressure to afford 350mg of the title compound. ¹H NMR (400 MHz, DMSO-d₆) δ ppm 6.71 (2H, bs),1.38 (9H, s).

The following sulfonamides (Int-16 to Int-19) are prepared following thesimilar procedure as mentioned in Int-15 using the appropriate sulfonylchloride.

Inter- ESMS mediate Structure IUPAC name (M + H) Int-16

1,2-dimethyl- 1H-imidazole- 5-sulfonamide m/z 176 Int-17

1-methyl-1H- pyrazole-5- sulfonamide m/z 162 Int-18

benzyl 4- sulfamoyl- piperidine- 1-carboxylate m/z 299 Int-19

6-methoxy- pyridine-3- sulfonamide m/z 189

Int-20: 4-(3-hydroxypyrrolidin-1-yl) benzene sulfonamide

A solution of 4-fluorobenzene sulfonamide (0.39 g, 2.22 mmol) andS(−)-3-hydroxypyrrolidine (0.32 g, 2.67 mmol) in DMSO (2 mL) was heatedto 100° C. for 20 h. Reaction was cooled to 25° C. and quenched withcold water. The separated solid was filtered and washed with water anddried to afford 4-(3-hydroxypyrrolidin-1-yl) benzene sulfonamide(Int-20) as a white solid. MS (ESI): m/z 243.1 (M+H).

The sulfonamides Int-21 to Int-23 are synthesized following theprocedure as mentioned in Int-20 using the appropriate aryl halides andamines.

ESMS Intermediate Structure IUPAC name (M + H) Int-21

4-morpholinobenzene- sulfonamide m/z 243 Int-22

(S)-6-(3- hydroxypyrrolidin-1- yl)pyridine-3- sulfonamide m/z 244 Int-23

6-(1H-1,2,4-triazol-1- yl)pyridine-3- sulfonamide m/z 226

Int-24: Benzyl cyclopropanesulfonate

Cyclopropyl sulfonyl chloride (2 g, 14.2 mmol) was added drop-wise at 0°C. to a solution of Benzyl alcohol (2.1 g, 28.4 mmol) and Pyridine (2.35g, 29.8 mmol) in DCM (20 mL) and continued stirring at 25° C. for 16 h.The reaction mixture was diluted with DCM (100 mL), washed with 1Naq.HCl solution followed by water and brine; Organic layer collected wasdried over anhydrous sodium sulphate and concentrated under reducedpressure to afford the Benzyl cyclopropanesulfonate. ¹H NMR (300 MHz,CD₃OD) δ ppm 4.3-4.1 (2H, t), 2.7-2.6 (1H, m), 1.8-1.6 (2H, m), 1.6-1.4(2H, m), 1.2-1.1 (4H, m), 1.0-0.9 (3H, t).

Int-25: Benzyl 1-methylcyclopropane-1-sulfonate

n-BuLi (0.78 g, 12.25 mmol) was added drop-wise at −78° C. to a solutionof Benzylcyclopropane sulfonate (2.0 g, 11.2 mmol) in THF (20 mL) andcontinued stirring at the same temperature for 10 min. CH₃I (3.98 g,28.0 mmol) was added at −78° C., allowed the reaction to warm to 0° C.with stirring for 30 min. The reaction mixture was quenched with icecold water, diluted with ethylacetate (100 mL), organic layer collectedwas dried over anhydrous sodium sulphate and concentrated under reducedpressure to afford the crude. The crude was purified by columnchromatography (using silica gel and 4% ethyl acetate in Hexane aseluent) to afford benzyl 1-methylcyclopropane-1-sulfonate (Int-25). ¹HNMR (300 MHz, CD₃OD) δ ppm 4.2-4.1 (2H, t), 1.7-1.6 (2H, m), 1.4 (3H,s), 1.5-1.3 (2H, m), 1.3-1.2 (2H, m), 1.0-0.9 (2H, m), 0.9 (3H, t).

Int-26: Potassium 1-methylcyclopropane-1-sulfonate

KSCN (2.48 g, 25.5 mmol) was added to a solution of Benzyl1-methylcyclopropane-1-sulfonate (4.9 g, 25.5 mmol) in DME/H₂O (1:1, 120mL) and continued stirring at 100° C. for 16 h. Reaction mixture wasconcentrated under reduced pressure and the residue was washed withn-Pentane and dried to afford Potassium 1-methylcyclopropane-1-sulfonate(Int-26) which was used in the next step without further purification.

Int-27: 1-Methylcyclopropane-1-sulfonamide

To a solution of Potassium 1-methylcyclopropane-1-sulfonate (4.44 g,25.5 mmol) in THF (50 mL) at 0° C. was added POCl₃ (11.7 g, 76.5 mmol)with stirring maintaining the same temperature for 30 min. DIPEA (9.8 g,76.5 mmol) was added to above mixture and continued stirring at 25° C.for 2 h. Reaction mixture was quenched with ice cold water, extractedinto diethyl ether (3×100 mL), dried over anhydrous sodiumsulphate toafford 1-methylcyclopropane-1-sulfonylchloride in diethyl ether. Theabove dried ethereal solution of 1-methylcyclopropane-1-sulfonylchloridewas cooled to −78° C. and purged in with NH₃ gas for 30 min. and slowlyallowed the reaction mixture to warm to 25° C. with stirring for 16 h.Reaction mixture was filtered through celite bed and the filtrate wasconcentrated under reduced pressure and the crude thus obtained waswashed with n-pentane to afford 1-methylcyclopropane-1-sulfonamide(Int-27) as pale brown solid. ¹H NMR (300 MHz, DMSO-d6) δ ppm 6.7 (2H,s), 1.4 (3H, s), 1.1-1.0 (2H, m) 0.7-0.6 (2H, m).

Int-28: 1-(4-Fluorobenzyl) cyclopropane-1-sulfonamide

The title compound Int-28 was prepared by the similar method asmentioned in Int-27 except in Int-25, 4-Fluoro benzyl bromide was usedin place of CH₃I to afford 1.1 g of Int-28 as pale brown solid. ¹H NMR(300 MHz, DMSO-d6) δ ppm 7.3-7.2 (5H, m), 6.9 (2H, s), 3.3 (2H, s)1.2-1.1 (2H, m), 0.5-0.4 (2H, m).

Int-29: 1-ethylcyclopropane-1-sulfonamide

The title compound Int-29 was prepared by the similar method asmentioned in Int-27 except in Int-25, ethyl iodide was used in place ofCH₃I to afford 0.9 g of Int-29 as pale brown solid.

Int-30: N-Ethyl-N-methyl sulfamide

N-Ethyl-N-methyl amine (2.95 g, 50 mmol) was added to a solution ofSulfamide (4 g, 41.6 mmol) in 1,4-Dioxane (40 mL) and continued stirringat 110° C. for 16 h. Reaction mass was concentrated under reducedpressure to afford the crude, which was purified by column purification(using neutral alumina and 10-70% ethyl acetate in Hexane as eluent) toafford N-Ethyl-N-methyl sulfamide (Int-30) as pale yellow oil. ¹H NMR(300 MHz, DMSO-d6) δ ppm 6.7 (2H, s), 3.1-2.3 (2H, m), 2.6 (3H, s),1.2-1.0 (3H, t).

Following sulfamides Int-31 and Int-35 were made using above methodexcept changing the amine

MS (ESI) Intermediate Structure IUPAC name (M + H) 31

N,N- Diethylsulfamide m/z 153.07 32

N,N- Dimethyl- sulfamide m/z 125.03 33

Piperidine-1- sulfonamide m/z 165.07 34

Pyrrolidine-1- sulfonamide m/z 151.03 35

Morpholine-4- sulfonamide m/z 167.03

Int-39: N-Ethyl-N-cyclopropyl sulfamide

Int-36: Tert-butyl (cyclopropylmethyl) carbamate

Di-tert-butyldicarbonate (6.13 g, 6.46 mL, 28.08 mmol) was added tosolution of Cyclopropyl methyl amine (2 g, 28.1 mmol), Et₃N (2.84 g,28.1 mmol) and DMAP (0.34 g, 2.8 mmol) in THF (20 mL) at 0-5° C. andstirring was continued at 25° C. for 3 h. Reaction mixture was dilutedwith ethyl acetate and the organic layer was washed with brine, followedby water, dried over anhydrous sodium sulphate and concentrated underreduced pressure to afford tert-butyl (cyclopropylmethyl) carbamate(Int-36) as pale yellow oil. ¹H NMR (300 MHz, DMSO-d6) δ ppm 7.0-6.7(2H, bs), 2.9-2.7 (2H, t), 1.3 (9H, s), 0.9-0.8 (1H, bs), 0.4-0.3 (2H,m), 0.1-0.05 (2H, m).

Int-37: Tert-butyl (cyclopropylmethyl) (methyl) carbamate

A solution of tert-butyl (cyclopropylmethyl)carbamate (4 g, 23.4 mmol)in DMF (35 mL) was added to a suspension of NaH (60% suspension inmineral oil) (0.58 g, 25.7 mmol) in DMF (5 mL) at 0-5° C., to it wasadded Iodomethane (2.5 mL, 40 mmol) and stirring was continued at 25° C.for 16 h. Reaction mixture was quenched with cold water, extracted withethyl acetate (3×50 mL), dried over anhydrous sodium sulphate andconcentrated under reduced pressure to afford the crude, which waspurified by flash chromatography (Biotage, Column: silica gel 12 g packsize, solid load, Mobile Phase: EtOAc in n-Hexane: 0 to 5% as eluent) toafford tert-butyl (cyclopropylmethyl)(methyl)carbamate (Int-37) as paleyellow oil. ¹H NMR (300 MHz, DMSO-d6) δ ppm 3.0-2.9 (2H, d), 2.85 (3H,s), 1.4 (9H, s), 0.9-0.7 (1H, bs), 0.5-0.3 (2H, m), 0.2-0.05 (2H, m).

Int-38:1-Cyclopropyl-N-methylmethanamine hydrochloride

Conc.HCl (0.6 mL) was added to a solution oftert-butyl(cyclopropylmethyl)(methyl)carbamate (2 g, 10.8 mmol) in H₂O(20 mL) at 0-5° C. and stirring was continued at 25° C. for 48 h.Reaction mixture was concentrated under reduced pressure to afford1-Cyclopropyl-N-methylmethanamine hydrochloride (Int-38) (1.24 g cr.).¹H NMR (300 MHz, DMSO-d6) δ ppm 2.9-2.8 (2H, d), 2.7 (3H, s), 1.1-1.0(1H, m), 0.7-0.6 (2H, m), 0.5-0.3 (2H, m), 0.4-0.3 (2H, m).

Int-39: N-Ethyl-N-cyclopropyl sulfamide

The title compound Int-39 was synthesized by a similar method as that ofInt-30 except Int-38 was used in place of N-Ethyl-N-methyl amine toafford N-Ethyl-N-cyclopropyl sulfamide (Int-39) as pale yellow oil. ¹HNMR (300 MHz, DMSO-d6) δ ppm 6.7 (2H, s), 2.8-2.7 (2H, d), 2.7 (3H, s),1.0-0.9 (1H, m), 0.5-0.4 (2H, m), 0.2-0.1 (2H, m).

Int-40: (R)-2-(2-Chloro-5-fluorophenyl) pyrrolidine hydrochloride(Int-40)

The title compound was prepared by the method similar to that mentionedfor Int-6 using 2-chloro-5-fluoro-1-bromobenzene in place of2,5-dilfuoro-1-bromobenzene to afford the title compound (Int-40) aspale pink solid. MS (ESI): m/z 200.1 (M+H).

Int-41: (R)-2-(5-Fluoro-2-methoxyphenyl) pyrrolidine hydrochloride

The title compound was prepared by the method similar to that mentionedfor Int-6 using 2-Bromo-4-fluoro-anisole in place of2,5-dilfuoro-1-bromobenzene to afford the title compound Int-41 as whitesolid. MS (ESI): m/z 195.9 (M+H).

Int-42: 2-Bromo-4-fluoro-1-(2-methoxyethoxy) benzene

1-bromo-2-methoxyethane (5.49 g, 39.5 mmol) was added to a mixture of2-bromo-4-fluoro phenol (5 g, 26.18 mmol) and K₂CO₃ (11.5 g, 83.25 mmol)in CH₃CN (41.5 mL) and continued stirring at 80° C. for 16 hr. Thereaction mixture was quenched with 1M aq.NaOH solution, extracted withdiethyl ether (3×100 mL), dried over anhydrous sodium sulphate andconcentrated under reduced pressure to afford the crude, which waspurified by column chromatography (using silica gel and 2% ethyl acetatein hexane as eluent) to afford the desired compound (Int-42). ¹H NMR(300 MHz, CDCl₃) δ ppm 7.3 (1H, m), 6.9 (1H, m), 6.7 (1H, m), 4.1 (2H,t), 3.8 (2H, t), 3.5 (3H, s).

Int-43: (R)-2-(5-Fluoro-2-(2-methoxyethoxy) phenyl) pyrrolidinehydrochloride

The title compound (Int-43) was prepared by the method similar to thatmentioned for Int-6 using 2-bromo-4-fluoro-1-(2-methoxyethoxy)benzene(Int-42) in place of 2,5-dilfuoro-1-bromobenzene to afford the desiredcompound (Int-43) as a solid. MS (ESI): m/z 240.2 (M+H).

Int-44: (R)-2-(3,5-Difluorophenyl) pyrrolidine hydrochloride

The title compound (Int-44) was prepared by the method similar to thatmentioned for Int-6 using 3,5-difluoro-1-bromobenzene in place of2,5-dilfuoro-1-bromobenzene to afford the title compound (Int-44) aswhite solid. MS (ESI): m/z 184 (M+H).

Int-46: (R)-2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidinehydrochloride

Int-45: 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene

To a solution of 3-bromo-5-fluorophenol (0.5 g, 2.6 mmol) in DMF (4.5mL) was added K₂CO₃ (0.9 g, 6.54 mmol) and stirred at 25° C. for 10 min.Water (0.5 mL) was added to the above mixture followed by addition of2-Chloro-2,2,-difluoroacetic acid sodium salt (0.6 g, 3.93 mmol) andstirring was continued at 100° C. for 3 h. The reaction mixture wascooled to 25° C. and diluted with ethyl acetate, washed with brine,dried over anhydrous sodium sulphate and concentrated under reducedpressure to afford the crude, which was purified by columnchromatography (using silica gel and 2% ethyl acetate in Hexane aseluent) to afford the desired compound (Int-45). ¹H NMR (400 MHz, CDCl₃)δ ppm 7.2-6.9 (2H, m), 6.8-6.7 (1H, d), 6.7-6.2 (1H, m).

Int-46: (R)-2-(3-(Difluoromethoxy)-5-fluorophenyl)pyrrolidinehydrochloride

The title compound (Int-46) was prepared by the method similar to thatmentioned for Int-6, using 1-bromo-3-(difluoromethoxy)-5-fluorobenzene(Int-45) in place of 2,5-dilfuoro-1-bromobenzene to afford the titlecompound (Int-46) as a thick brown liquid. MS (ESI): m/z 232.2 (M+H).

Int-47: Synthesis of (2R,4S)-2-(2, 5-difluorophenyl)-4-fluoropyrrolidinehydrochloride

The title compound was prepared by the method similar to that mentionedin WO2009140128 to afford Int-47 as off white solid. MS (ESI): m/z 202.1(M+H).

Int-48: Synthesis of (R)-2-(2, 5-difluorophenyl)-4,4-difluoropyrrolidine hydrochloride

The title compound Int-48 was prepared by following the method similarto that mentioned in WO2009140128. MS (ESI): m/z 220.4 (M+H).

Int-56: Synthesis of 2-(7-fluoro-2, 3-dihydrobenzo[b] [1,4]dioxin-5-yl)pyrrolidine

Int-49: 1-(5-Fluoro-2-hydroxy-3-nitrophenyl) ethanone

Conc. HNO₃ (22.49 g, 357 mmol) was added to a solution1-(5-fluoro-2-hydroxyphenyl) ethanone (50 g, 325 mmol) in acetic acid(300 mL) at 0° C. and stirring was continued at 20° C. for 3 h. Thereaction mixture was quenched with ice cold water. The separated solidwas filtered and washed with cold water and dried to afford1-(5-fluoro-2-hydroxy-3-nitrophenyl) ethanone (Int-49) as pale yellowsolid. ¹H NMR (400 MHz, DMSO-d6) δ ppm 12.6 (1H, s), 8.3-8.2 (1H, dd),8.2-8.1 (1H, dd), 2.7 (3H, s).

Int-50: 5-Fluoro-3-nitrobenzene-1,2-diol

H₂SO₄ (50 mL) was added to a solution of H₃BO₃ (89.3 g, 1.4 mol) in1,4-Dioxane (300 mL) at 0° C. and stirred at 28° C. for 1 h.1-(5-fluoro-2-hydroxy-3-nitrophenyl) ethanone (50 g, 289 mmol) was addedportion wise to the above solution over 1 h, maintaining the temperatureat 0° C., after addition was complete, the reaction mixture was warmedto 25° C. and stirred for 16 h. Reaction mixture was quenched with coldwater, solid separated was collected by filtration. The solid wassuspended in diethyl ether (500 mL) and filtered to remove insolubleinorganic mass, ether layer was washed with cold water (2 to 3 times)followed by brine, dried over anhydrous sodium sulphate and concentratedunder reduced pressure to afford the crude sticky solid. The crude solidwas triturated over n-Hexane and filtered to afford5-fluoro-3-nitrobenzene-1,2-diol (Int-50) as pale yellow solid. MS(ESI): m/z 171.9 (M-1).

Int-51: 7-Fluoro-5-nitro-2, 3-dihydrobenzo[b] [1, 4] dioxine

K₂CO₃ (15.27 g, 110.6 mmol) was added to a solution of5-fluoro-3-nitrobenzene-1,2-diol (5 g, 28.9 mmol) in DMF (35 mL)followed by the addition of 1,2-Dibromoethane (13.63 g, 6.25 mL, 72.5mmol) and stirring was continued at 80° C. for 2 h. Reaction mixture wasdiluted with ethyl acetate, washed with cold water, dried over anhydroussodium sulphate and concentrated under reduced pressure to afford thecrude, which was purified by MPLC (silica gel, Mobile Phase: ethylacetate in n-Hexane 0 to 5% as eluant) to afford7-fluoro-5-nitro-2,3-dihydrobenzo[b] [1,4]dioxine (Int-51) as paleyellow solid. ¹H NMR (300 MHz, CDCl₃) δ ppm 7.3-7.2 (1H, dd), 6.9-6.8(1H, dd), 4.4 (4H, s).

Int-52: 7-Fluoro-2, 3-dihydrobenzo[b] [1, 4] dioxin-5-amine

10% Pd/C (400 mg) was added to a solution of7-fluoro-5-nitro-2,3-dihydrobenzo[b][1,4]dioxine (2.0 g, 10 mmol) inmethanol (50 mL) and stirring was continued at 25° C. under H₂atmosphere for 3 h. The reaction mixture was filtered over celite bedand washed with methanol. The filtrate and the washings wereconcentrated under reduced pressure to afford7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-amine (Int-52) as pale brownliquid. MS (ESI): m/z 170.1 (M+H).

Int-53: 5-Bromo-7-fluoro-2, 3-dihydrobenzo[b] [1, 4] dioxine

NaNO₂ (2.69 g, 39.9 mmol) in water (20 mL) was added slowly at 0° C. toa solution of 7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-amine (4.5 g, 26mmol) in aq. 47% HBr (20 mL) and continued stirring at same temperaturefor 30 min. The above diazonium salt solution was added slowly to asolution of CuBr (5.7 g, 39.9 mmol) in aq. 47% HBr (25 mL) at 0° C. andstirred at 25° C. for 30 min. Reaction mixture was quenched with icewater, extracted with ethyl acetate (3×50 mL), washed it with waterfollowed by brine, dried over anhydrous sodium sulphate and concentratedunder reduced pressure to afford crude. The crude was purified by columnpurification (using silica gel and 0-5% ethyl acetate in Hexane aseluent) to afford 5-bromo-7-fluoro-2,3-dihydrobenzo[b] [1,4] dioxine(Int-53) (5.9 g). ¹H NMR (300 MHz, CDCl₃) δ ppm 6.9-6.84 (1H, dd),6.6-6.5 (1H, dd), 4.3-4.3 (4H, m).

Int-54:Tert-butyl-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-2-hydroxypyrrolidine-1-carboxylate

A solution of isopropyl magnesium chloride in THF (2M, 5.39 mL, 10.78mmol) was added to a solution of 5-bromo-7-fluoro-2, 3-dihydrobenzo[b][1,4] dioxine (Int-53) (1 g, 4.31 mmol) in THF (10 mL) at −45° C.drop-wise and then allowed it to warm up to 5° C. over a period of 1 h.The reaction mixture was cooled again to −45° C. and a solution oftert-butyl 2-oxopyrrolidine-1-carboxylate (1.6 g, 8.62 mmol) in THF (10mL) was added drop-wise maintaining the temperature at −45° C. Thereaction mixture was warmed to 25° C. and stirred for 1 h and thenquenched with saturated NH₄Cl solution (100 mL). The reaction mixturewas extracted with ethyl acetate (3×30 mL) and the organic layer wasdried over anhydrous sodium sulphate and concentrated under reducedpressure and purified by column chromatography (using silica gel and 20%ethyl acetate Hexane as eluent) to afford tert-butyl5-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate(Int-54). MS (ESI) m/z 340 (M-+1).

Int-55: 5-(7-Fluoro-2, 3-dihydrobenzo[b] [1, 4]dioxin-5-yl)-3,4-dihydro-2H-pyrrole

TFA (0.09 mL, 1.18 mmol) was added to a solution of tert-butyl5-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate(0.04 g, 0.117 mmol) in DCM (5 mL) at 0° C. and stirring was continuedat 25° C. for 3 h. Reaction mixture was concentrated under reducedpressure to afford the crude, which was diluted with ethyl acetate,washed with saturated NaHCO₃ solution, dried over anhydrous sodiumsulphate to afford5-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3,4-dihydro-2H-pyrrole(Int-55). MS (ESI) m/z 222 (M+H)

Int-56: 2-(7-Fluoro-2, 3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidine

NaBH₄ (0.25 g, 6.69 mmol) was added to a solution of5-(7-fluoro-2,3-dihydrobenzo [b][1,4]dioxin-5-yl)-3,4-dihydro-2H-pyrrole(Int-55) (0.8 g, 3.34 mmol) in a mixture of MeOH and H₂O (3:1, 20 mL)and was stirred at 25° C. for 2 h. Reaction mixture was quenched with 1Naqueous HCl solution (50 mL) and basified with 2N aqueous NaOH solutionto pH 8 and extracted with DCM (3×20 mL). The organic layer was driedover anhydrous sodium sulphate and concentrated under reduced pressureto afford 2-(7-fluoro-2, 3-dihydrobenzo[b] [1,4]dioxin-5-yl)pyrrolidine(Int-56). MS (ESI) m/z 224.5 (M+H).

Above enatiomeric mixture was separated in a prerprative chiral HPLCcolumn (Chiral pak IC (10 mm×250 mm×5 u) flow: 7 mL/min;95:5:Hexane:0.1% ethanolamine in EtOH (isocratic) to afford two isomer,240 mg (Int-56A) and 233 mg (Int-56B)

Int-57: (4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2, 5-difluorophenyl)pyrrolidine hydrochloride

TFA (0.27 mL, 0.414 g, 3.63 mmol) was added to a solution of(4R)-tert-butyl 4-((tert-butyldimethylsilyl) oxy)-2-(2,5-difluorophenyl) pyrrolidine-1-carboxylate (0.5 g, 1.21 mmol) in DCM(10 mL) at 0° C. and stirring was continued at 28° C. for 2 hr. Reactionmixture was concentrated under reduced pressure to afford(4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2, 5-difluorophenyl)pyrrolidine hydrochloride (Int-57). MS(ESI) m/z 200 (M-TBDMS+1, freebase)

Int-58: Ethyl 5-((4R)-2-(2, 5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylate

The title compound (Int-58) was prepared by the method similar to thatmentioned for Int-84, by using ethyl 5-bromopyrazolo [1, 5a]pyridine-3-carboxylate and (4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2,5-difluorophenyl) pyrrolidine hydrochloride (Int-57) to afford (0.26 g,crude) as white solid after in situ deprotection of OTBDMS group tohydroxyl moiety. MS (ESI) m/z 388.1 (M+H)

Int-59: Ethyl 5-((4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxylate

TBDMSCl (0.093 g, 0.62 mmol) was added at 0° C. to a solution of Ethyl5-((4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl) pyrazolo[1,5-a] pyridine-3-carboxylate (Int-58) (0.2 g, 0.52 mmol) in DMF (5 mL)followed by Imidazole (0.1 g, 1.55 mmol) and continued stirring at 28°C. for 1 hr. The reaction mixture quenched with ice water, extractedinto DCM, dried over anhydrous sodium sulfate and concentrated underreduced pressure to afford 5-((4R)-4-((tert-butyldimethylsilyl)oxy)-2-(2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxylate (Int-59) (0.28 g, Crude) as Brown oil.

Int-60: Ethyl 5-((2R, 4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxylate (Isomer-I)

The diastereomeric mixture (Int-59) obtained was purified by FlashChromatography (Biotage, Column: Silicagel 25 g pack size, Mobile Phase:EtOAc in n-Hexane: 0 to 12% as eluant) to afford ethyl 5-((2R,4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxylate (Isomer-I)(Int-60) as yellow solid. MS(ESI) m/z 502.2 (M+H) and

Int-61: Ethyl 5-((2S, 4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a]pyridine-3-carboxylate (Isomer-II)

as yellow solid. MS(ESI) m/z 502 (M+H)

Int-62: 5-((2R, 4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo [1, 5-a]pyridine-3-carboxylic acid

1M aq. solution of LiOH.H₂O (0.4 mL) was added to a stirred solution ofethyl 5-((2R, 4R)-4-((tert-butyldimethylsilyl) oxy)-2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxylate (Isomer-I) (Int-60) (0.07 g, 0.14 mmol) in EtOH(5 mL) and the stirring was continued at 90° C. for 8 h. The reactionmixture was concentrated under reduced pressure to afford the crudeproduct. The crude product thus obtained was diluted with cold water,acidified with citric acid solution, filtered the solid precipitated toafford 5-((2R, 4R)-2-(2, 5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylic acid (Int-62) as yellow solid.MS (ESI): m/z 360 (M+H).

Int-63: Ethyl 5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxylate (Isomer-I)

The title compound (Int-63) was prepared by the method similar to thatfor Int-84 using 2-(7-fluoro-2, 3-dihydrobenzo[b] [1, 4]dioxin-5-yl)pyrrolidine ((Int-56A) and Ethyl 5-bromopyrazolo [1, 5-a]pyridine-3-carboxylate to afford as pale brown solid. LCMS (ESI): m/z412.85 (M+H).

Int-64: 5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)pyrrolidin-1-yl) pyrazolo[1, 5-a] pyridine-3-carboxylic acid (Isomer-I)

The title compound (Int-64) was prepared by the method similar to thatof Int-85 employing Int-63 to afford as white solid. LCMS (ESI): m/z384.2 (M+H).

Int-65: Ethyl 5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxylate (Isomer-II)

The title compound (Int-65) was prepared by the method similar to thatof Int-84 using 2-(7-fluoro-2, 3-dihydrobenzo[b] [1, 4] dioxin-5-yl)pyrrolidine (Int-56B)) and Ethyl 5-bromopyrazolo [1, 5-a]pyridine-3-carboxylate to afford as pale brown solid. LCMS (ESI): m/z412.85 (M+H).

Int-66: 5-(2-(7-fluoro-2, 3-dihydrobenzo [b] [1, 4] dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1, 5-a] pyridine-3-carboxylic acid (Isomer-II)

The title compound (Int-66) was prepared by the method similar to thatof Int-64 employing Int-65 to afford as white solid. LCMS (ESI): m/z384.2 (M+H).

Int-67: Ethyl 5-((2R, 4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo [1, 5-a]pyridine-3-carboxylate

The title compound (Int-67) was prepared by the method similar to thatfor Int-84 using (2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidinehydrochloride (Int-47) and Ethyl 5-bromopyrazolo [1, 5-a]pyridine-3-carboxylate to afford as yellow solid. LCMS (ESI): m/z 390.8(M+H).

Int-68: 5-((2R, 4S)-2-(2, 5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylic acid

The title compound (Int-68) was prepared by the method similar to thatof Int-85 employing Int-67 to afford as white solid. LCMS (ESI): m/z362.8 (M+H).

Int-69: (R)-Ethyl 5-(2-(2-chloro-5-fluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylate

A mixture of ethyl 5-bromopyrazolo[1,5a]pyridine-3-carboxylate (1.3 g,4.85 mmol), (R)-2-(2-chloro-5-fluorophenyl) pyrrolidine hydrochloride(Int-40) (1.13 g, 4.85 mmol) and K₃PO₄ (3.08 g, 14.5 mmol) in1,4-Dioxane (20 mL) was degassed with argon gas for 15 min. Pd₂(dba)₃(0.313 g, 0.34 mmol) and BINAP (0.24 g, 0.39 mmol) were added to theabove mixture and stirring was continued at 100° C. for 2 h. Aftercompletion of the reaction, the reaction mixture was cooled and filteredover a celite bed. The celite bed was washed with ethylacetate. Thefiltrate thus obtained was further washed with water, dried overanhydrous sodium sulphate and concentrated under reduced pressure toafford the crude product, which was purified by column chromatography(using silica gel and 20% EtOAc in Hexane as eluant) to afford (R)-Ethyl5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate(Int-69) as a white solid. MS (ESI): m/z 388.1 (M+H).

Int-70: (R)-Ethyl5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Cs₂CO₃ (0.75 g, 2.32 mmol) in 1,4-Dioxane (10 mL) was degassed withargon gas for 15 min. Pd(OAc)₂ (0.052 g, 0.23 mmol) and X-Phos (0.22 g,0.45 mmol) were added to the above mixture and degassed with argon gasfor 15 min. (R)-Ethyl 5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylate (Int-69) (0.3g, 0.77 mmol) followed by 4-Fluorophenylboronic acid (0.54 g, 3.87 mmol)and again degassed with argon gas for 15 min. KI (0.025 g, 0.25 mmol)was added to the above mixture and stirring was continued at 100° C. for20 h. The reaction mixture was cooled to 28° C., diluted with EtOAc,filtered through whatman filter paper filtrate collected was washed withwater, dried the organic layer over anhydrous sodium sulphate andconcentrated under reduced pressure to afford the crude product, whichwas purified by Flash Chromatography (Biotage, Column: Silicagel 12 gpack size, Mobile Phase: EtOAc in n-Hexane: 0 to 15% as eluant) toafford (R)-Ethyl 5-(2-(4, 4′-difluoro-[1, 1′-biphenyl]-2-yl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxylate (Int-70) asoff white sticky mass. MS (ESI): m/z 448.8 (M+H).

Int-71: (R)-5-(2-(4, 4′-difluoro-[1, 1′-biphenyl]-2-yl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylic acid

The title compound (Int-71) was prepared by the method similar that ofInt-85 employing Int-70 to afford as white solid. MS (ESI): m/z 420.2(M+H).

Int-72: Ethyl 5-(2-(2, 5-difluorophenyl)-4, 4-difluoropyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylate

The title compound (Int-72) was prepared by the method similar to thatfor Int-84 using (R)-2-(2,5-difluorophenyl)-4, 4-difluoropyrrolidinehydrochloride and Ethyl 5-bromopyrazolo [1, 5-a] pyridine-3-carboxylateto afford as yellow solid. LCMS (ESI): m/z 408.1 (M+H).

Int-73: 5-(2-(2, 5-difluorophenyl)-4, 4-difluoropyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylic acid

The title compound (Int-73) was prepared by the method similar to thatof Int-85 employing Int-72 to afford as white solid. LCMS (ESI): m/z379.8 (M+H).

Int-74: Ethyl 5-((2R, 4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxylate

The title compound (Int-74) was prepared by the method similar to thatfor Int-84 using (2R, 4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidinehydrochloride (Int-48) and Ethyl 5-bromopyrazolo [1,5-a]pyridine-3-carboxylate to afford as yellow liquid. LCMS (ESI): m/z 390.2(M+H).

Int-75: 5-((2R, 4R)-2-(2, 5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylic acid

The title compound (Int-75) was prepared by the method similar to thatof Int-85 using Int-74 to afford as off white solid. LCMS (ESI): m/z362.2 (M+H).

Int-76: (R)-ethyl 5-(2-(5-fluoro-2-hydroxyphenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxylate

To a stirred solution of (R)-ethyl5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate(synthesized similar to that of Int-84 using intermediate 41) (1.2 g,3.13 mmol) in 25 mL of DCM, 1.0M Borontribromide (15.6 ml, 39.2 g, 15.65mmol) was added at −70° C. and stirred at −70° C. to room temperatureduring 16 h. Reaction mass was quenched with 5 mL of ice cooled waterand stirred for 15 min. The reaction mixture was diluted with DCM (50mL) and the organic layer was washed with water followed by brine. Theorganic layer was dried over anhydrous sodium sulphate and concentratedunder reduced pressure to afford of the title compound (Int-76) as offwhite solid. MS (ESI): m/z 370.3 (M+H).

Int-78:(R)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid

Int-77:(R)-ethyl5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Iodoethane (0.17 g, 1.08 mmol) was added to a mixture of (R)-ethyl5-(2-(5-fluoro-2-hydroxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate(Int-76) (0.2 g, 0.54 mmol) and K₂CO₃ (0.23 g, 1.62 mmol) in CH₃CN (10mL) and continued stirring at 80° C. for 16 h. The reaction mixture wasdiluted with ethyl acetate (100 mL), washed with water and dried overanhydrous sodium sulphate and concentrated under reduced pressure toafford the crude, which was purified by column chromatography (usingsilica gel and 2% ethyl acetate in hexane as eluent) to afford thedesired compound (Int-77). MS (ESI): m/z 398.1 (M+H).

Int-78:(R)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid

1M aq. solution of LiOH.H₂O (0.4 mL) was added to a stirred solution of(R)-ethyl5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate(Int-77) (0.12 g, 0.32 mmol) in ethanol (5 mL) and the stirring wascontinued at 90° C. for 8 h. The reaction mixture was concentrated underreduced pressure to afford the crude, which was diluted with cold water(20 mL) and acidified with 2N HCl solution to pH=2, solid precipitatedout was filtered and dried to afford the desired compound (Int-78) asyellow solid. MS (ESI): m/z 370.3 (M+H).

The following intermediates (Int-79 to Int-83) were prepared by a methodsubstantially similar to that mentioned for Int-78 except a suitablealky halides or O-mesylates was used in place of ethyl iodide in Int-77.

MS (ESI) Intermediate Structure IUPAC name (M + H) Int-79

(R)-5-(2-(5-fluoro-2- (2,2,2-trifluoroethoxy) phenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxylic acid m/z 424.1 Int-80

5-((2R)-2-(5-fluoro-2- ((tetrahydrofuran-3- yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxylic acid m/z 412.1 Int-81

(R)-5-(2-(2-(cyclopropyl- methoxy)-5-fluoro- phenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxylic acid m/z 396.1 Int-82

(R)-5-(2-(5-fluoro-2-(2- fluoroethoxy)phenyl)-pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxylic acid m/z 388.1Int-83

(R)-5-(2-(5-fluoro-2-(2- methoxyethoxy)phenyl)-pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxylic acid m/z 400.1

Int-84: (R)-ethyl 5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5a]pyridine-3-carboxylate

A mixture of ethyl 5-bromopyrazolo[1,5a]pyridine-3-carboxylate (2 g,7.49 mmol), (R)-2-(2, 5-difluorophenyl) pyrrolidine hydrochloride(Int-6) (1.65 g, 7.49 mmol) and Cs₂CO₃ (7.3 g, 22.47 mmol) in1,4-Dioxane (35 mL) was degassed with argon gas for 15 min. Pd₂(dba)₃(480 mg, 0.52 mmol) and BINAP (380 mg, 0.59 mmol) were added to theabove mixture and stirring was continued at 100° C. for 2 h. Aftercompletion of the reaction, the reaction mixture was cooled and filteredover a celite bed. The celite bed was washed with ethylacetate. Thefiltrate thus obtained was further washed with water, dried overanhydrous sodium sulphate and concentrated under reduced pressure toafford the crude product, which was purified by column chromatography(using silica gel 60-120, and 30% EtOAc in Hexane as eluent) to afford1.8 g of the title compound as a yellow solid.

¹H NMR (300 MHz, CDCl₃) δ ppm 8.21-8.18 (2H, m), 7.12-7.02 (1H, m),6.98-6.86 (1H, m), 6.74-6.66 (1H, m), 6.28-6.2 (1H, m), 5.15 (1H, d, J=8Hz), 6.16-6.13 (1H, m), 5.11 (1H, d, J=8.1 Hz), 4.34-4.27 (2H, m), 3.84(1H, t) 3.60-3.5 (1H, m), 2.52-2.4 (1H, m), 2.2-2.0 (3H, m), 1.38-1.3(3H, m).

MS (ESI): m/z 372 (M+H).

Int-85: (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5a]pyridine-3-carboxylic acid

LiOH.H₂O (0.679 mg, 16.2 mmol) in water (5 mL) was added to a stirredsolution of Int-84 (1.8 g, 4.85 mmol) in EtOH (30 mL) and the stirringwas continued at reflux temperature for 12-16 h. The reaction mixturewas concentrated under reduced pressure to afford the crude product. Thecrude product thus obtained was diluted with cold water, acidified with2N aqueous HCl solution, filtered the solid precipitate to afford 1.2 gof the title compound as an off white solid.

MS (ESI): m/z 344 (M+H).

Int 87: 5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5a]pyridine-3-carboxylic acid

Int-86: Ethyl5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

The title compound was prepared by a procedure substantially similar asfor Int-84, using Int-10 in place of Int-6 to afford the crude. Thecrude compound was purified by column chromatography (using silica gel60-120, and 5% EtOAc in Hexane as eluent) to afford 135 mg of the titlecompound.

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.52-8.50 (1H, d, J=7.6 Hz), 8.12 (1H,s), 7.4-7.3 (1H, m), 7.2-7.1 (1H, m), 6.95-6.9 (1H, m), 6.7 (1H, s),6.55 (1H, bs), 5.12 (1H, d, J=7.6 Hz), 4.2-4.27 (2H, m), 3.94-3.84 (1H,t), 3.55-3.40 (1H, m), 2.52-2.40 (1H, m), 2.15-1.85 (3H, m), 1.3-1.15(3H, m),

MS (ESI): 372 (M+H).

Int-87: 5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5a]pyridine-3-carboxylic acid

5N aqueous solution of NaOH (2 mL) was added to stirred solution ofInt-86 (50 mg, 0.134 mmol) in a mixture of MeOH (4 mL) and THF (4 mL)and continued stirring at 80° C. for 4 h. The reaction mixture wasconcentrated under reduced pressure to afford the crude product. Thecrude product thus obtained was diluted with cold water, acidified withconcentrated HCl solution to obtain a solid precipitate. This solidprecipitate was filtered and dried well to afford 18 mg of5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid as off white solid.

¹H NMR (400 MHz, DMSO-d₆) δ ppm 11.82 (1H, s), 8.46 (1H, d, J=7.6 Hz),8.08 (1H, s), 7.40-7.30 (1H, m), 7.20-7.10 (1H, m), 6.95-6.88 (1H, m),6.67 (1H, s), 6.39 (1H, s), 5.15 (1H, d, J=8 Hz), 3.80-3.70 00 (1H, t,J=8 Hz), 3.50-3.30 (1H, m), 2.44 (1H, m), 2.10-1.85 (3H, m).

MS (ESI): m/z 344.2 (M+H).

Int-89:(R)-5-(2-(5-(difluoromethoxy)-2-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid

Int-88: (R)-2-(5-(difluoromethoxy)-2-fluorophenyl) pyrrolidinehydrochloride

This compound was prepared by the method substantially similar to thepreparation of Int-6 using 2-bromo-4-(difluoromethoxy)-1-fluorobenzene(J. Med. Chem. 2003, 46, 1016-1030).

Int-89: (R)-Ethyl 5-(2-(5-(difluoromethoxy)-2-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

The title compound was prepared by the method substantially similar tothat for Int-84, to afford the crude, which was purified by columnchromatography (using silica gel 60-120, and 5% EtOAc in Hexane aseluent) to afford 140 mg of the title compound.

MS (ESI): m/z 420 (M+H).

Int-90:(R)-5-(2-(5-(difluoromethoxy)-2-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid

The title compound was prepared by the method substantially similar tothat for Int-85, to afford 85 mg of the title compound.

¹H NMR (300 MHz, DMSO-d₆) δ ppm 11.9 (1H, bs,), 8.47-8.45 (1H, d, J=7.5Hz), 8.08 (1H, s), 7.37-7.30 (1H, t), 7.20-7.10 (1H, m), 6.87-6.85 (1H,m), 7.33-6.87 (1H, t, OCHF₂) 6.76 (1H, bs), 6.45-6.35 (1H, m), 5.16-5.14(1H, d, J=7.5 Hz), 3.90-3.80 (1H, t), 3.55-3.45 (2H, m), 2.08-1.85 (3H,m).

MS (ESI): m/z 392.1 (M+H).

Int-91(R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid

Title compound was prepared by a method substantially similar to that ofInt-84 using ethyl 5-bromopyrazolo[1,5a]pyridine-3-carboxylate and(R)-2-(3,5-Difluorophenyl) pyrrolidine hydrochloride (Int-44), followedby hydrolysis similar to that of Int-85 to afford a white solid.

MS (ESI): m/z 344.2 (M+H).

Synthesis of Compounds of Formula I Example-1:(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

EDCI (111 mg, 0.5 mmol) was added to a solution of(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylicacid (100 mg, 0.29 mmol) in DCM (4 mL) followed by DMAP (36 mg, 0.29mmol) and 4-fluorobenzenesulfonamide (56 mg, 0.31 mmol) and stirring wascontinued at 20-35° C. for 20 h. Reaction mixture was quenched withwater, extracted into EtOAc, dried over anhydrous sodium sulphate andconcentrated under reduced pressure to afford the crude. The crudecompound was purified by Preparative HPLC [Column: 21.2×150×5 um,Zorbax, Eclipse, C-18, Mobile phase-A: Water, B:ACN, Gradient(Time/% B):0/30, 2/40, 10/80 and Flow rate:20 mL/min] to afford 9.3 mg of the titlecompound.

¹H NMR (400 MHz, CDCl₃) δ ppm 8.29 (1H, bs), 8.22-8.20 (2H, m), 8.12(1H, d, J=7.6 Hz), 8.00 (1H, s), 7.26-7.20 (2H, m), 7.14-7.04 (2H, m),6.96-6.88 (1H, m), 6.61 (1H, m), 6.18 (1H, d, J=7.6 Hz), 5.12-5.11 (1H,d, J=8 Hz), 3.80-3.74 (1H, m), 3.6-3.5 (1H, m), 2.5-2.4 (1H, m),2.15-2.0 (3H, m).

MS (ESI): m/z 501.8 (M+H).

Example-2: (R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide

To a stirred solution of (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid (170 mg, 0.49mmol) in dry DCM (10 mL) was added EDCI (288 mg, 1.5 mmol) followed byDMAP (0.18 g, 1.4 mmol) and stirring was continued at 25° C. for 2 h. Tothe reaction mixture was added tert-butyl sulfonamide (67 mg, 0.49 mmol)and the stirring was continued at 25° C. for 72 h. Reaction mixture wasdiluted with DCM (50 mL) and the organic layer was washed with saturatedaqueous KHSO₄ solution followed by brine, dried over anhydrous sodiumsulphate and concentrated under reduced pressure to afford the crude,which was purified by combiflash chromatography followed byre-crystalisaiton from EtOH to afford(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide as white solid.MS (ESI): m/z 463.2 (M+H).

Example-3: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

The title compound was prepared by the method substantially similar tothat mentioned in Example-2 using Ethanesulfonamide to afford the crude.The crude compound was purified by Preparative HPLC [Column: 21.2×150×5um, Zorbax, Eclipse, C-18, Mobile phase-A: 0.1% TFA in Water, B:ACN,Gradient(Time/% B): 0/30, 2/40, 5/80 and Flow rate:20 mL/min] to afford12 mg of the title compound.

¹H NMR (300 MHz, CD₃OD) δ ppm 8.32-8.29 (2H, m), 7.22-7.12 (1H, m),7.08-6.96 (2H, m), 6.8-6.72 (1H, m), 6.50 (1H, m), 5.2-5.18 (1H, d,J=6.8 Hz), 3.9-3.82 (1H, m), 3.6-3.48 (3H, m), 2.5 (1H, m), 2.18-2.0(3H, m), 1.4-1.3 (3H, t).

MS (ESI): m/z 434.8 (M+H).

Example-4:(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

The title compound was prepared by the similar coupling method asmentioned in Example-2, using 3-cyanobenzenesulfonamide to afford thecrude. The crude was purified by Preparative HPLC [Column: 21.2×150×5um, Zorbax, XDB, C-18(#22), Mobile phase-A: 0.1% TFA in water, B:ACN,Gradient (Time/% B): 0/30, 5/40, 6/80 and flow rate: 20 mL/min] toafford 46 mg of the title compound.

¹H NMR (400 MHz, DMSO-d₆) δ ppm 12.05 (1H, s), 8.51 (1H, s), 8.42-8.45(1H, d, J=7.6 Hz), 8.37 (1H, s), 8.30-8.18 (2H, m), 7.89-7.85 (1H, t),7.36-7.28 (1H, m), 7.18-7.10 (1H, m), 6.90-6.75 (2H, m), 6.39 (1H, bs),5.14-5.13 (1H, d, J=7.2 Hz), 3.83-3.81 (1H, t), 3.48-3.38 (1H, m),2.50-2.42 (1H, m), 2.10-1.85 (3H, m).

MS (ESI): m/z 507.8 (M+H).

Example-5:(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

The title compound was prepared by a coupling method substantiallysimilar to that mentioned in Example-2 using cyclopropane sulfonamide inplace of 4-fluorobenzenesulfonamide to afford the crude. The crude waspurified by Preparative HPLC [Column: 19×150×5 um, Zorbax, XDB,C-18(#22), Mobile phase-A: 0.1% TFA in water, B:ACN, Gradient (Time/%B): 0/30, 2/40, 10/80 and flow rate: 20 mL/min] to afford 8 mg of thetitle compound.

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.51-8.49 (2H, m), 7.40-7.30 (1H, m),7.20-7.12 (1H, m), 6.95-6.85 (2H, m), 6.46-6.40 (1H, bs), 5.20-5.15 (1H,d, J=7.6 Hz), 3.92-3.85 (1H, m), 3.50-3.42 (1H, m), 3.18-3.10 (1H, m),2.50-2.41 (1H, m), 2.10-1.85 (3H, m), 1.14-1.02 (4H, m).

MS (ESI): m/z 446.8 (M+H).

Example-6:(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

The title compound was prepared by the similar coupling method asmentioned in Example-2, using Methane sulfonamide to afford the crude.The crude was purified by Preparative HPLC [Column: 19×150×5 um,Xbridge, C-18(#22), Mobile phase-A: 0.1% TFA in water, B:ACN, Gradient(Time/% B): 0/40, 2/40, 7/60 and flow rate: 15 mL/min] to afford 16 mgof the title compound.

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.54-8.46 (2H, m), 7.38-7.30 (1H, m),7.20-7.12 (1H, m), 6.96-6.64 (2H, m), 6.48-6.40 (1H, bs), 5.17-5.16 (1H,d, J=8.4 Hz), 3.89-7.81 (1H, t), 3.50-3.40 (1H, m), 3.33 (3H, s),2.50-2.45 (1H, m), 2.10-1.88 (3H, m).

MS (ESI): m/z 421.2 (M+H).

Example-7 to Example-41 were synthesized following a proceduresubstantially similar to Example-2 except appropriate sulfonamide wasused in place of tert-butyl sulfonamide to afford the desired product.

Example MS(ESI) No. Structure IUPAC name M + H  7

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(isopropyl-sulfonyl)pyrazol[1,5-a]pyridine- 3-carboxamide m/z 449.3  8

5-((R)-2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 568.2  9

(R)-N-((3-cyanophenyl)sulfonyl)- 5-(2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-N-methylpyrazolo[1,5- a]pyridine-3-carboxamide m/z522.2 10

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(propyl-sulfonyl)pyrazolo[1,5-a]pyridine- 3-carboxamide m/z 449.1 11

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamidem/z 502.2 12

(R)-N-(cyclohexylsulfonyl)-5- (2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 489.3 13

(R)-N-(cyclopentylsulfonyl)-5- (2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 475.1 14

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(isobutyl-sulfonyl)pyrazolo[1,5-a]pyridine- 3-carboxamide m/z 463.1 15

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-4-yl)sulfonyl)- pyrazolo[1,5-a]pyridine-3- carboxamide m/z501.1 16

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 501.1 17

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamide m/z 490.1 18

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z487.3 19

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z487.4 20

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((2,4-dimethylthiazol-5-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamidem/z 518.0 21

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z552.1 22

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 491.223

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-(dimethylamino)pyridin-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 527.1 24

5-((R)-2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 491.1 25

5-((R)-2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin- 3-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 569.1 26

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z514.1 27

(R)-N-((6-(1H-1,2,4-triazol-1- yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin- 1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 551.2 28

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z487.1 29

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z568.0 30

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 484.1 31

(R)-N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2,5-difluoro-phenyl)pyrrolidin-1-yl)- pyrazolo[1,5-a]pyridine-3- carboxamide m/z523.0 32

(R)-N-((2,5-dichlorothiophen-3- yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamidem/z 556.7 33

(R)-N-(cyclobutylsulfonyl)-5-(2- (2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 461.1 34

(R)-5-(2-(2,5- difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4] dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 541.1 35

(R)-N-(benzo[d][1,3]dioxol-5- ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamidem/z 527.1 36

(R)-5-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z475.4 37

(R)-5-(2-(2,5- difluorophenyl)pyrrolidin-1-yl)- N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 477.4 38

(R)-5-(2-(2,5-difluorophenyl)- pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)- pyrazolo[1,5-a]pyridine-3- carboxamide m/z461.1 39

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 498.05 40

(R)-N-(benzylsulfonyl)-5-(2- (2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 497.2 41

(R)-5-(2-(2,5- difluorophenyl)pyrrolidin-1-yl)- N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 555.442

(R)-N-(tert-butylsulfonyl)-5-(2- (5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 475.0 43

(R)-N-(tert-butylsulfonyl)-5-(2- (3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z510.9 44

(R)-N-(tert-butylsulfonyl)-5-(2- (5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 446.1 45

(R)-N-(tert-butylsulfonyl)-5-(2- (2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 488.9 46

(R)-N-(tert-butylsulfonyl)-5-(2- (2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z514.8 47

(R)-N-(tert-butylsulfonyl)-5-(2- (2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 479.1 48

N-(tert-butylsulfonyl)-5- ((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z478.9 49

(R)-N-(tert-butylsulfonyl)-5-(2- (5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 542.7 50 (Isomer- I)

N-(tert-butylsulfonyl)-5-(2-(7- fluoro-2,3-dihydrobenzo[b][1,4]-dioxin-5-yl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z503.4 51 (Isomer- II)

N-(tert-butylsulfonyl)-5-(2-(7- fluoro-2,3-dihydrobenzo[b][1,4]-dioxin-5-yl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide 52(Isomer- I)

N-(tert-butylsulfonyl)-5-((2R,4S)- 2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 481.253 (Isomer- II)

N-(tert-butylsulfonyl)-5- ((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z481.3 54

(R)-N-(tert-butylsulfonyl)-5-(2- (4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 539.1 55(Isomer- I)

(S)-N-(tert-butylsulfonyl)-5-(2- (2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)- pyrazolo[1,5-a]pyridine-3- carboxamide m/z499.25 56 (Isomer- II):

(R)-N-(tert-butylsulfonyl)-5-(2- (2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)- pyrazolo[1,5-a]pyridine-3- carboxamide m/z499.45 57

(R)-N-(tert-butylsulfonyl)-5-(2- (5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 507.158

N-(tert-butylsulfonyl)-5-((2R,4R)- 2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 481.159

N-(tert-butylsulfonyl)-5-((2R)-2- (5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamidem/z 531.6 60:

N-(tert-butylsulfonyl)-5-((2R)-2- (5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamidem/z 531.6 61

(R)-N-(tert-butylsulfonyl)-5-(2- (2,5-difluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a] pyridine-3-carboxamide m/z 481.1 62

(R)-N-(tert-butylsulfonyl)-5-(2- (2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4- fluoropyrazolo[1,5-a]pyridine-3-carboxamide m/z 529.1 63

(R)-N-(tert-butylsulfonyl)-5-(2- (2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z511.1 64

(R)-N-(tert-butylsulfonyl)-5-(2- (2-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)- pyrazolo[1,5-a]pyridine-3- carboxamide m/z519.2 65

(R)-N-(tert-butylsulfonyl)-5-(2- (5-fluoro-2-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 519.166

(R)-N-(tert-butylsulfonyl)-5-(2- (3,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 463.1 67

(R)-N-(tert-butylsulfonyl)-5-(2- (3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 519.268

N-(tert-butylsulfonyl)-5-((2R)-2- (3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamidem/z 531.2 69

(R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluoro-phenyl)sulfonyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 501 70

5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 568.1 71

(R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-(isopropyl-sulfonyl)pyrazolo[1,5-a]pyridine- 3-carboxamide m/z 449.1 72

(R)-N-((6-(1H-1,2,4-triazol-1- yl)pyridin-3-yl)sulfonyl)-5-(2-(3,5-difluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 551.1 73

5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin- 3-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 568.9 74

5-((2R,4S)-2-(2,5-difluoro- phenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 479.1 75

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 467.2

Example-76: (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo [1, 5-a]pyridine-3-carboxamide

To a stirred solution of (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid (0.1 g, 0.29mmol) in DCM (20 mL), added EDCI (0.084 g, 0.43 mmol) followed by DMAP(0.18 g, 1.4 mmol) and stirring was continued at 28° C. for 16 hr. Tothe above reaction added 1,1,-dimethyl sulfamide (0.09 g, 0.69 mmol),stirring was continued at 28° C. for 48 hr. Reaction mixture was dilutedwith DCM, washed it with saturated KHSO₄ solution followed by brine,dried over anhydrous sodium sulphate and concentrated under reducedpressure to afford the crude. The crude obtained was purified bypreparative HPLC (AG/AD/PP/C18-25/033, Flow rate: 20 mL/min., Mobilephase: 0.1% TFA in water (A): ACN (B), Gradient—Time: % B=0: 20, 2: 30,10: 70) to afford (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo [1, 5-a]pyridine-3-carboxamide as pale pink solid. MS (ESI): m/z 450.3 (M+H).

¹HNMR (300 MHz, DMSO-d6): δ ppm 11.2 (1H, s), 8.6-8.4 (2H, m), 7.2-7.1(1H, m), 7.1-7.05 (1H, m,), 7.0-6.8 (2H, m), 6.5-6.3 (1H, d), 5.25-5.08(1H, d), 3.95-3.75 (1H, m), 3.55-3.4 (1H, m), 2.84 (6H, s), 2.15-2.85(3H, m).

Following acylsulfamides Example-77 to Example-116 were synthesized by asimilar procedure as that of Example-76.

Example 77

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(N-ethyl-N-methylsulfamoyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 463.8 78

5-((2R,4S)-2-(2,5-difluoro- phenyl)-4-fluoropyrrolidin-1-yl)-N-(N,N-dimethyl- sulfamoyl)pyrazolo[1,5- a]pyridine-3-carboxamidem/z 468.1 79

5-((2R,4S)-2-(2,5-difluoro- phenyl)-4-fluoropyrrolidin-1-yl)-N-(N-ethyl-N-methyl- sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 482.1 80

(R)-N-(N- (cyclopropylmethyl)-N- methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamidem/z 490.6 81

(R)-N-(N,N- diethylsulfamoyl)-5-(2-(2,5- difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 478.1 82

5-((2R,4S)-2-(2,5-difluoro- phenyl)-4-fluoropyrrolidin-1- yl)-N-(N,N-dimethylsulfamoyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 468.1 83

5-((2R,4S)-2-(2,5-difluoro- phenyl)-4-fluoropyrrolidin-1-yl)-N-(N-ethyl-N- methylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide m/z 482.1 84

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N- (morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 492.1 85

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 476.3 86

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl) sulfonyl)pyrazolo[1,5- a]pyridine-3-carboxamidem/z 505.2 87

(R)-N-(N,N- diethylsulfamoyl)-5-(2-(5- fluoro-2-methoxy-phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 490.188

(R)-N-(N,N- diethylsulfamoyl)-5-(2-(5- fluoro-2-(2-fluoro-ethoxy)phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamidem/z 522.55 89

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamide m/z 490.5 90

(R)-5-(2-(3,5-difluoro-2- methoxyphenyl)pyrrolidin-1-yl)-N-(N-ethyl-N-methyl- sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 494.5 91

(R)-N-(N-ethyl-N- methylsulfamoyl)-5-(2-(5- fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 476.55 92

(R)-N-(N-ethyl-N-methyl- sulfamoyl)-5-(2-(5-fluoro-2- (2-fluoroethoxy)phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 508.693

5-((R)-2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(((S)-3-hydroxypyrrolidin-1-yl) sulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamidem/z 492.3 94

(R)-5-(2-(3,5-difluoro-2-(2- fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-ethyl-N- methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 525.8 95

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-sulfamoyl-pyrazolo[1,5-a]pyridine-3- carboxamide m/z 422.3 96

N-(N-ethyl-N- methylsulfamoyl)-5-(2-(8- fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-I) m/z 518.2 97

N-(N-ethyl-N- methylsulfamoyl)-5-(2-(8- fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diasteromer-II) m/z 518.2 98

N-(N,N-dimethylsulfamoyl)- 5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide (Diastereomer-I) m/z 490.2 99

N-(N,N-dimethylsulfamoyl)- 5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin- 5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide (Diastereomer- II) m/z 489.8100

N-(N-ethyl-N- methylsulfamoyl)-5-(2-(7- fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin- 1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer- I) m/z 504.1 101

N-(N-ethyl-N- methylsulfamoyl)-5-(2-(7- fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin- 1-yl)pyrazolo[1,4-a]pyridine-3-carboxamide (Diastereomer- II) m/z 504.1 102

N-(N-ethyl-N- methylsulfamoyl)-4-fluoro-5- ((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z481.8 103

N-(N-ethyl-N- methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran- 3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 532.4 104

(R)-5-(2-(3,5-difluoro-2- ((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1- yl)-N-(N-ethyl-N-methyl-sulfamoyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 564.2 105

(R)-5-(2-(3,5-difluoro-2- ((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)- N-(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 549.8 106

N-(N-ethyl-N-methyl- sulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3- yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 532.4 107

4-fluoro-5-((2R,4S)-4-fluoro- 2-(3-fluorophenyl)pyrrolidin- 1-yl)-N-sulfamoylpyrazolo[1,5- a]pyridine-3-carboxamide m/z 539.7 108

N-(N,N-dimethylsulfamoyl)- 5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6- yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide (Diastereomer-I) m/z 503.8 109

N-(N,N-dimethylsulfamoyl)- 5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6- yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide (Diastereomer-2) m/z 504.1 110

(R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(N- isobutyl-N-methylsulfamoyl)pyrazolo [1,5-a]pyridine-3-carboxamide m/z 491.8 111

(R)-N-(N-ethyl-N-methyl- sulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z464.2 112

(R)-N-(N,N- dimethylsulfamoyl)-4-fluoro- 5-(2-(3-fluoro-phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 450.1113

(R)-N-(N,N- dimethylsulfamoyl)-4-fluoro- 5-(2-(3-fluoro-phenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 450.1114

(R)-N-(N-ethyl-N-methyl- sulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H- pyran-4- yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 546.2 115

5-((2R)-2-(3-((2,2-difluoro- cyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)- N-(N-ethyl-N-methyl-sulfamoyl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 552.40

Examples 116 to Example-127 were synthesized following a proceduresimilar to Example-2, except that an appropriate acid counter part wasused in place (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid and appropritesulfonamides were used in place t-butylsulfonamide to afford the desiredproduct.

Example 116

(R)-N-(N,N- bis(cyclopropylmethyl)sulfamoyl)- 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5- a]pyridine-3-carboxamide m/z 529.8 117(Diastere- omer-I)

N-(N-ethyl-N-methyl- sulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3- yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 532.1 118 (Diastere-omer-II)

N-(N-ethyl-N-methyl- sulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy) phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 532.2 119

N-(tert-butylsulfonyl)-5-(2-(2,5- difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide (Racemic mixture) 120

(R)-N-(tert-butylsulfonyl)-5-(2- (3,5-difluoro-2-methoxy-phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 493.3121

N-(tert-butylsulfonyl)-4-fluoro- 5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z481.05 122

4-fluoro-5-((2R,4S)-4-fluoro-2- (3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z467.2 123

(R)-N-(tert-butylsulfonyl)-5-(2- (3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 563.50 124

(R)-N-(tert-butylsulfonyl)-5-(2- (5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide m/z 545.50 125

(R)-5-(2-(3,5-difluoro-2- ((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)- N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 549.2 126

(R)-4-fluoro-5-(2-(3- fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo[1,5-a]pyridine-3- carboxamide m/z 449.2127

(R)-N-(tert-butylsulfonyl)-4- fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4- yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3- carboxamide m/z 532.2General Procedure for Salt Synthesis:

Above examples 1-127 can be converted to a pharmaceutically acceptablesalt by reacting with a suitable salt, by reacting a solution of thecompound (1-127) with suitalble salt. For example a solution of thecompound of (1-127)(1 eq) in water sodium hydroxide or potassiumhydroxide or calcium hydroxide (1M, 1 eq.) can be added drop wise and tobe stirred for 1 h at 25° C.−100° C. Reaction mixture shall be cooledand filtered and the filtrate to be concentrated to get required salt aswhite powder compound.

Illustrative examples of the salts prepared are as given below:

Example 128

HNMR (400 MHz, DMSO-D6) δ 8.4-8.3 (d, 1H), 7.95 (s, 1H), 7.3- 7.2 (m,1H), 7.2-7.09 (m, 3H), 6.6 (dd, 1H), 5.55-4.9 (d, IH), 5.3-5.2 (m, 1H),4.15-4.0 (m, 1H), 3.8-3.65 (m, 1H), 2.95-2.8 (m, 1H), 2.3-2.1 (m, 1H),1.25 (s, 9H); LCMS (ESI) m/z 481.1 129

¹HNMR (400 MHz, DMSO-D6) δ 8.35-8.333 (d, 1H), 7.93 (s, 1H), 7.32-7.27(m, 1H), 7.15-7.10 (m, 1H), 7.04 (s, 1H), 6.84-6.79 (m, 1H), 6.28-6.26(dd, 1H), 5.07-5.05 (dd, 1H), 3.80-3.76 (m, 1H), 3.40- 3.38 (m, 1H),2.46-2.42 (m, 1H), 2.04-2.02 (m, 1H), 1.93-1.85 (m, 2H), 1.25 (s, 9 H);LC-MS (API) 463.1 130

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.31-8.29 (1H, d), 7.91 (1H, s), 7.10(1H, s), 6.66-6.62 (1H, dd), 6.25-6.22 (1H, dd), 6.13-6.12 (1H, m),5.01-4.99 (1H, d), 4.38-4.28 (4H, m), 3.72-3.68 (1H, t), 2.36- 2.31 (1H,m), 2.02-1.99 (1H, m), 1.93-1.87 (2H, m), 1.28 (9H, s); MS (ESI): m/z502.8 131

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.42-8.40 (1H, d), 8.00-7.90 (1H, s),7.30-7.29 (1H, dt), 7.17- 7.09 (1H, m) 7.04 (1H, s), 6.82- 6.80 (1H, m),6.40-6.30 (1H, d), 5.59-5.46 (1H, m), 5.19-5.16 (1H, d), 4.03-4.96 (1H,m), 3.85-3.73 (1H, m), 2.88-2.66 (1H, m), 2.32- 2.24 (1H, m), 1.22 (9H,s); MS (ESI): m/z 481.5 132

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.35-8.33 (1H, d), 7.91 (1H, s),7.33-7.27 (1H, m), 7.15-7.10 (1H, m), 7.06 (1H, s), 6.85-6.81 (1H, m),6.31-6.29 (1H, d), 5.06- 5.04 (1H, d), 3.83-3.79 (1H, t), 3.44-3.38 (1H,q), 2.06-2.02 (1H, m), 1.93-1.85 (2H, m); MS (ESI): m/z 449.8 133

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.44-8.42 (1H, d), 7.95 (1H, s),7.36-7.30 (1H, m), 7.19-7.15 (1H, m), 7.05-7.04 (1H, d), 7.00- 6.95 (1H,m), 6.37-6.35 (1H, dd), 5.35-5.32 (1H, d), 4.25-4.23 (1H, m), 3.98-3.93(1H, m), 1.21 (9H, s); MS (ESI): m/z 499.1 134

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.32-8.30 (1H, d), 7.93 (1H, s),7.32-7.26 (1H, m), 7.15-7.10 (2H, m), 6.90-6.80 (1H, m), 6.22- 6.21 (1H,d), 5.11-5.09 (1H, d), 3.79-3.78 (1H, m), 2.04-1.88 (3H, m), 1.14 (2H,m), 0.50 (2H, m); MS (ESI): m/z 461.8 135

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.42-8.40 (1H, d), 7.95 (1H, s),7.33-7.27 (1H, m), 7.15-7.10 (1H, m), 7.05 (1H, s), 6.84-6.81 (1H, m),6.36-6.35 (1H, d), 5.59- 5.46 (1H, m), 5.18-5.16 (1H, d), 4.06-3.96 (1H,m), 3.85-3.73 (1H, dd), 2.91-2.76 (1H, m), 2.32-2.25 (1H, m), 1.22 (9H,s); MS (ESI): m/z 480.8 136

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.35-8.34 (1H, d), 7.93 (1H, s),7.31-7.25 (1H, m), 7.16-7.13 (2H, m), 7.10-7.04 (1H, m), 6.34- 6.32 (1H,dd), 5.56-5.43 (1H, m), 5.23-5.18 (1H, t), 4.16-4.03 (1H, m), 3.81-3.72(1H, m), 2.92-2.81 (1H, m), 2.52-2.44 (6H, s), 2.17- 2.11 (1H, m); MS(ESI): m/z 468.8 137

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.77-8.75 (1H, d), 7.92 (1H, s),7.34-7.28 (2H, m), 7.17-7.12 (2H, m), 7.03-6.98 (1H, m), 5.51- 5.38 (1H,m), 5.11-5.07 (1H, m), 4.31-4.18 (1H, m), 3.70-3.62 (1H, m), 2.85-2.76(1H, m), 2.48-1.99 (1H, m), 1.25 (9H, s); MS (ESI): m/z 481.8 138

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.68-8.66 (1H, d), 7.92 (1H, s),7.35-7.29 (2H, m), 7.07-6.98 (3H, m), 5.09-5.08 (1H, m), 3.88- 3.86 (1H,m), 3.55-3.52 (1H, m), 2.56 (6H, s), 2.00-1.89 (2H, m), 1.86-1.84 (1H,m); MS (ESI): m/z 449.8 139

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.30-8.29 (1H, d), 7.90 (1H, s),7.08-7.03 (3H, m), 6.70-6.67 (1H, m), 6.10 (1H, bs), 5.16 (1H, m),4.99-4.97 (1H, m), 3.94-3.88 (2H, m), 3.85-3.73 (3H, m), 3.39- 3.37 (2H,m), 2.98-2.92 (2H, m), 2.54 (3H, s), 2.40-2.32 (2H, m), 2.28-2.23 (1H,m), 2.14-2.00 (1H, m), 1.86-1.84 (2H, m), 1.05-1.01 (3H, t); MS (ESI):m/z 531.8 140

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.30-8.29 (1H, d), 7.90 (1H, s),7.90-7.80 (1H, d), 7.40-7.03 (7H, m), 6.90-81 (1H, m), 6.18 (1H, bs),5.10-5.05 (1H, m), 3.74-3.70 (2H, m), 2.01-1.89 (4H, m); MS (ESI): m/z497.1 141

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.76-8.74 (1H, d), 7.91 (1H, s),7.51-7.49 (1H, d), 7.32 (2H, bs), 7.24-7.22 (1H, d), 7.03-7.00 (1H, m),5.52-5.39 (1H, m), 5.02-4.98 (1H, m), 4.38-4.24 (1H, m), 3.71- 3.63 (1H,m), 3.50-3.42 (1H, m), 2.80-2.73 (1H, m), 2.17-2.06 (1H, m), 1.15-1.11(6H, d); MS (ESI): m/z 467.35 142

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.33-8.31 (1H, d), 7.93 (1H, s),7.30-7.25 (1H, m), 7.16-7.11 (3H, m), 6.28-6.27 (1H, d), 5.58- 5.44 (1H,m), 5.25-5.21 (1H, t), 4.15-4.04 (1H, m), 3.79-3.71 (1H, m), 2.88-2.80(1H, m), 2.92-2.12 (1H, m), 1.38 (3H, s) 1.16 (2H, m), 0.51 (2H, m); MS(ESI): m/z 479.40 143

¹H NMR (400 MHz, DMSO-d₆) δ ppm 8.30-8.28 (1H, d), 7.93 (1H, s),7.33-7.27 (1H, m), 7.21 (1H, bs), 7.16-7.10 (1H, m), 6.89-6.85 (1H, m),6.15-6.14 (1H, d), 5.13- 5.11 (1H, d), 3.82-3.79 (1H, t), 3.44-3.38 (1H,q), 3.02 (4H, t), 2.04-1.89 (3H, m), 1.53-1.51 (4H, m), 1.43-1.42 (2H,m); MS (ESI): m/z 489.8

Example-144

Determination of In Vitro TrkA Inhibitory Activity Using TR-FRET Assay

Compounds were screened in the TR-FRET assay with TrkA kinase. 5 ng ofTrkA [Upstate, USA] kinase was used for assay. The compound wasincubated with the kinase for 30 minutes at 20-35° C. After theincubation, substrate mix [40 nM Ultra light poly GT (Perkin Elmer, USA)and 500 μM ATP] was added. The above reaction was stopped by theaddition of 40 mM EDTA after 30 minutes. The Eu-labelledantiphospho-tyrosine antibody [Perkin Elmer, USA] was added at 0.5 nMand the fluorescence emission at 615 nm/665 nm [excitation at 340 nm]was measured. The compounds were initially screened at 100 nM, 1 μM and10 μM concentrations. The potent compounds with >25% inhibition at 1 μMof TrkA were taken for the full dose response studies. The final DMSOconcentration in the assay was 1%. For IC₅₀ determination, ⅓^(rd) serialdilution was made from the 20 mM DMSO stock solution. 2 μl of these weretransferred to the test wells containing 20 μl reaction mixture [Totalreaction volume 22 μl]. The fluorescence was measured in Perkin ElmerWallac 1420 Multilabel Counter Victor 3. The IC₅₀ was determined byfitting the dose response data to a sigmoidal curve fitting equationusing GraphPad Prism software version 5.

Using this protocol, various compounds as described herein and furtheras exemplified above, were found to exhibit inhibitory effect on TrkA(Table 2).

Examples 2, 7, 8, 9, 10, 25, 31, 39, 40, 41, 52, 57, 59, 65, 70, 73, 74,76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 87, 88, 89, 90, 91, 94, 128,132, 136, 137, 138, 139, 140, 141, 142 and 143, as described herein,exhibited a TrkA inhibition in-vitro IC₅₀ values less than or equal toabout 50 nM;

Examples 4, 26, 34, 35, 38, 44, 45, 46, 47, 60, 63 and 134, as describedherein, exhibited a TrkA inhibitory activity in-vitro IC₅₀ valuesbetween about 50 nm and about 100 nM;

Examples 1, 3, 5, 6, 11, 12, 13, 14, 19, 20, 22, 23, 24, 27, 28, 29, 32,33, 36, 37, 43, 49, 50, 54, 56, 61, 62, 66, 71, 72, 75, 86, 93, 130 and133, as described herein, exhibited a TrkA inhibitory activity in-vitroIC₅₀ values between about 100 nm to about 500 nm;

Examples 15, 21, 30, 48, 58, 67, 68, 69 and 131, as described herein,exhibited a TrkA inhibitory activity in-vitro IC₅₀ values between about500 nm to about 1 μM;

Examples 16, 17, 18, 51, 53, 55 and 135, as described herein, exhibiteda TrkA inhibitory activity in-vitro IC₅₀ values between about 1 μM toabout 10 μM.

Example-145

Stability Protocol: Metabolic Stability Using Rat Liver Microsomes (RLM)and Human Liver Microsomes (HLM).

This assay was performed using pooled male rat liver microsomes(In-house prepared as per SOP), Pooled Human liver microsomes (XENOTECH;Batch No-H0630-1110189)). The 100 μl reaction contains the compounds at1 μM, 0.3 mg/ml microsomal protein and both the co-factors (1 mM NADPH)in buffer and the mixture was incubated at different time points (0, 15,30, 45, 60, & 90 minutes). The reaction was stopped by the addition ofequal volume of acetonitrile containing internal standard (Telmesartin).The precipitated protein was removed by centrifugation and thesupernatant were analyzed LC/MS-MS method. The percent parent compoundremaining was quantified by analysis using following formula (% parentcompound remaining=(peak area at Time x/peak area at T0)×100. Theintrinsic clearance was calculated using the following formula.CL_(int,app): (0.693/in vitro t1/2) (incubation volume/mg of microsomalprotein) (45 mg microsomal protein/gram of liver) (20^(a) g of liver/kgbody weight)

-   -   a: 20 and 45 g of liver/kg of body weight were used for human        and rat, respectively (Lu C et al., DMD, 2006).        Bio-analysis: It was performed in Multiple Reaction Monitoring        mode (negative mode) using Applied Biosystems API 4000 coupled        to Agilent Technologies 1100 series HPLC on a reverse phase        column (Zorbax Eclipse XDB C18, 50×4.6 mm, 5 am). Celecoxib was        used as internal standard both in in-vitro and in-vivo        experiments. Mobile phase used 0.05% monofluoro acidic water and        acetonitrile (10:90) with a flow rate of 0.6 ml/minute. The        injection volume was kept as 10 μl.        Examples 1, 2, 3, 4, 10, 24, 25, 26, 35, 38, 39, 40, 42, 43, 45,        46, 50, 52, 57, 59, 65, 74, 75, 76, 77, 78, 79, 91, 96, 102,        106, 107, 121, 122 and 124 as described herein, exhibited        metabolic stablility half life (in minutes) of >80, by using        Human Liver Microsomes,

Example-146: Apparent Aqueous Solubility Assay

The 10 mM DMSO solution of test compounds or reference standards wereadded to Dulbeco's phosphate buffer saline pH 7.4 (DPBS) and DMSO in a96 deep-well plate to generate theoretical concentration of 200 μM. Thesolutions were equilibrated by shaking (200 rpm, Ika plate shaker) for16 hours at 25° C. Undissolved compound was removed by centrifugation,and the supernatant was analyzed by HPLC-UV. The assays were performedin duplicates. Aqueous solubility was calculated using the equation:Aqueous solubility=200 μMXPA_(PBS)/PA_(DMSO)Whereas PA_(PBS) and PA_(DMSO) are the peak areas from the analyses oftest compound in PBS with 2% DMSO and of test compound in 100% DMSO,respectively.

Although the present application has been illustrated by certain of thepreceding examples, it is not to be construed as being limited thereby;but rather, the present application encompasses the generic area ashereinbefore disclosed. Various modifications and embodiments can bemade without departing from the spirit and scope thereof. For example,the following compounds, their pharmaceutically acceptable salts,pharmaceutically acceptable solvates or stereoisomers thereof are alsoincluded in the scope of the present application.

The invention claimed is:
 1. A method for treating a cancer associatedwith a Trk kinase activity in a mammal in need thereof, the methodcomprising administering to the mammal a therapeutically effectiveamount of a compound of Formula (I),

or their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein A is

X¹ is CH or N; R¹ represents hydrogen or —(C₁-C₆)alkyl; R² isindependently selected from hydrogen, halogen, cyano, —(C₁-C₆)alkyl,-halo(C₁-C₆)alkyl, -halo(C₁-C₆)alkoxy, phenyl optionally substitutedwith 1 to 3 halogens; and an optionally substituted —O-heterocyclicwherein the optional substituent is alkyl, —OR^(i) or —C(O)N(R^(i))₂;when X¹ is CH, optionally two R²s present on any two adjacent carbonatoms combine to form a 5 to 7 membered heterocyclic ring; R³ isindependently halogen, cyano, —OR^(i), or —C(O)N(R^(i))₂ or two R³stogether with the carbon atom they are attached form a (C₃-C₇)cycloalkylgroup spiro attached to pyrrolidine; or two R³ when they are attached toadjacent carbon atoms form a (C₃-C₇)cycloalkyl ring fused to thepyrrolidine; R^(a) is selected from (i) a group selected from optionallysubstituted —(C₁-C₆)alkyl, -hydroxy(C₁-C₆)alkyl and—(C₁-C₆)alkyl-(C₁-C₆)alkoxy, wherein the optional substituent is cyano,halogen or —(C₆-C₁₂)aryl, (ii) an optionally substituted—(C₃-C₁₀)cycloalkyl wherein the optional substituent is cyano,—(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s), (iii) an optionallysubstituted —(C₆-C₁₂)aryl wherein the optional substituent is cyano,hydroxyl, halogen, —(C₁-C₆)alkyl or —R^(r) (iv) an optionallysubstituted 5 to 10 membered heterocyclyl, wherein the optionalsubstituent is cyano, hydroxyl, halogen or —(C₁-C₆)alkyl, (v) anoptionally substituted 5 to 10 membered heteroaryl, wherein the optionalsubstituent is cyano, oxo (═O), hydroxyl, halogen, —(C₁-C₆)alkyl,—(C₁-C₆)alkoxy, —NR^(c)R^(d) or —R^(r) (vi) —NR⁴R⁵, and (vii)—(C₁-C₆)alkyl-(C₆-C₁₂)aryl; R^(b) represents hydrogen or halogen; R⁴ isselected from hydrogen, —(C₁-C₆)alkyl, —(C₃-C₁₀)cycloalkyl,-hydroxy(C₁-C₆)alkyl, -alkoxy(C₁-C₆)alkyl, -halogen(C₁-C₆)alkyl and—(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl; R⁵ is hydrogen or —(C₁-C₆)alkyl or—(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl; Alternatively R⁴ and R⁵ together withthe nitrogen atom to which they are attached may form an optionallysubstituted 5 to 10 membered heterocyclic ring, optionally containing1-2 additional heteroatoms or groups selected from —O—, —S—, —N—,—C(═O)—, —S(═O)— or —S(═O)₂—, wherein the optional substituent ishydroxyl, —(C₁-C₆)alkyl, —C(═O)—(C₁-C₆)alkyl, mesyl or COOR^(e); R^(c)and R^(d) are independently selected from hydrogen and —(C₁-C₆)alkyl;R^(e) is selected from hydrogen and alkyl; R^(i) is hydrogen,—(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl, —(C₁-C₆)alkyl-(C₁-C₆)alkoxy,—(C₃-C₁₀)cycloalkyl, optionally substituted—(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl, wherein the optional substituent ishalogen or —(C₁-C₆)alkyl substituted with 1 to 3 hydroxy groups; R^(r)is independently selected from a 5 to 10 membered heterocyclyl or a 5 to10 membered heteroaryl, wherein optional substituent is hydroxyl,halogen, —(C₁-C₆)alkyl or —(C₁-C₆)alkoxy; R^(s) is an optionallysubstituted —(C₁-C₆)alkyl-(C₆-C₁₀)aryl, wherein the optional substituentis halogen; m is independently represents 0, 1, 2, 3 or 4; and n isindependently represents 0, 1, 2, or
 3. 2. The method of claim 1,wherein the Trk kinase is TrkA.
 3. The method of claim 1, wherein thecompound of Formula (I) is

or their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein the values of all thevariables are as described in claim
 1. 4. The method of claim 1, whereinR^(b) is hydrogen, fluorine; R³ is fluorine; or R² is independentlyrepresents halogen, cyano or haloalkyl; R⁴ and R⁵ are methyl, ethyl orpropyl; m is 1 or 2; or R^(a) methyl, ethyl, propyl, isopropyl, butyl ortert-butyl.
 5. The method of claim 1, wherein the compound of formula(I) is(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclohexylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-(cyclopentylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclobutylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (S)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)-4, 4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)-4, 4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-((6-(1H-1, 2, 4-triazol-1-yl)pyridin-3-yl) sulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N—(N, N-dimethylsulfamoyl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-1),N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2);(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture);(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo [1,5-a] pyridine-3-carbonyl)amide, Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide, Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide, Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carbonyl)amide, Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carbonyl)amide, Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide,Sodium (4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (isopropylsulfonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,or Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide;or a pharmaceutically acceptable salt thereof, a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 6. The method ofclaim 1, wherein the compound of formula (I) is(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((3-cyanophenyl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide; (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo [1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture),(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(cyclohexyl sulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-(cyclopentylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(cyclobutylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a]pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((6-(1H-1, 2, 4-triazol-1-yl) pyridin-3-yl) sulfonyl)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide; (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo [1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide;(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(isopropylsulfonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(R)-(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide;N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II), orN—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2); or a pharmaceutically acceptable salt thereof, apharmaceutically acceptable solvate thereof or a stereoisomer thereof.7. The method of claim 1, wherein the compound of formula (I) is(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-methoxyethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-cyclopropyl-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methylphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-fluoroethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-hydroxyethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N-(azetidin-1-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-(2-cyanoethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N,N-dimethylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(7-fluoro-3-(fluoromethyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(3-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-(2-(9-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N,N-dimethylsulfamoyl)-5-(2-(9-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-((1-(hydroxymethyl)cyclobutyl)methyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

(R)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide H

N-(azetidin-1-ylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide

N-(azetidin-1-ylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide

or a pharmaceutically acceptable salt thereof, a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 8. The method ofclaim 1, wherein the compound of formula (I) is

or a pharmaceutically acceptable salt thereof, or a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 9. The method ofclaim 1, wherein the compound of formula (I) is a pharmaceuticalcomposition comprising at least one compound of compound of formula (I)and at least one pharmaceutically acceptable excipient.
 10. A method oftreating a cancer in a subject, the method comprising: a) determiningthat the cancer is associated with an abnormal or deregulated Trkkinase; and b) administering to the subject a therapeutically effectiveamount of a dosage form comprising a compound of Formula (I)

or their pharmaceutically acceptable salts, pharmaceutically acceptablesolvates or stereoisomers thereof, wherein A is

X¹ is CH or N; R¹ represents hydrogen or —(C₁-C₆)alkyl; R² isindependently selected from hydrogen, halogen, cyano, —(C₁-C₆)alkyl,-halo(C₁-C₆)alkyl, -halo(C₁-C₆)alkoxy, phenyl optionally substitutedwith 1 to 3 halogens; and an optionally substituted —O-heterocyclylwherein the optional substituent is alkyl, —OR^(i) or —C(O)N(R^(i))₂;when X¹ is CH, optionally two R²s present on any two adjacent carbonatoms combine to form a 5 to 7 membered heterocyclic ring; R³ isindependently halogen, cyano, —OR^(i), or —C(O)N(R^(i))₂ or two R³stogether with the carbon atom they are attached form a (C₃-C₇)cycloalkylgroup spiro attached to pyrrolidine; or two R³ when they are attached toadjacent carbon atoms form a (C₃-C₇)cycloalkyl ring fused to thepyrrolidine; R^(a) is selected from (i) a group selected from optionallysubstituted —(C₁-C₆)alkyl, -hydroxy(C₁-C₆)alkyl and—(C₁-C₆)alkyl-(C₁-C₆)alkoxy, wherein the optional substituent is cyano,halogen or —(C₆-C₁₂)aryl, (ii) an optionally substituted—(C₃-C₁₀)cycloalkyl wherein the optional substituent is cyano,—(C₁-C₆)alkyl, hydroxyl, halogen or —R^(s), (iii) an optionallysubstituted —(C₆-C₁₂)aryl wherein the optional substituent is cyano,hydroxyl, halogen, —(C₁-C₆)alkyl or —R^(r) (iv) an optionallysubstituted 5 to 10 membered heterocyclyl, wherein the optionalsubstituent is cyano, hydroxyl, halogen or —(C₁-C₆)alkyl, (v) anoptionally substituted 5 to 10 membered heteroaryl, wherein the optionalsubstituent is cyano, oxo (═O), hydroxyl, halogen, —(C₁-C₆)alkyl,—(C₁-C₆)alkoxy, —NR^(c)R^(d) or —R^(r), (vi) —NR⁴R⁵, and (vii)—(C₁-C₆)alkyl-(C₆-C₁₂)aryl; R^(b) represents hydrogen or halogen; R⁴ isselected from hydrogen, —(C₁-C₆)alkyl, —(C₃-C₁₀)cycloalkyl,-hydroxy(C₁-C₆)alkyl, -alkoxy(C₁-C₆)alkyl, -halogen(C₁-C₆)alkyl and—(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl; R⁵ is hydrogen or —(C₁-C₆)alkyl or—(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl; Alternatively R⁴ and R⁵ together withthe nitrogen atom to which they are attached may form an optionallysubstituted 5 to 10 membered heterocyclic ring, optionally containing1-2 additional heteroatoms or groups selected from —O—, —S—, —N—,—C(═O)—, —S(═O)— or —S(═O)₂—, wherein the optional substituent ishydroxyl, —(C₁-C₆)alkyl, —C(═O)—(C₁-C₆)alkyl, mesyl or COOR^(e); R^(c)and R^(d) are independently selected from hydrogen and —(C₁-C₆)alkyl;R^(e) is selected from hydrogen and alkyl; R^(i) is hydrogen,—(C₁-C₆)alkyl, -halo(C₁-C₆)alkyl, —(C₁-C₆)alkyl-(C₁-C₆)alkoxy,—(C₃-C₁₀)cycloalkyl, optionally substituted—(C₁-C₆)alkyl-(C₃-C₁₀)cycloalkyl, wherein the optional substituent ishalogen or —(C₁-C₆)alkyl substituted with 1 to 3 hydroxy groups; R^(r)is independently selected from a 5 to 10 membered heterocyclyl or a 5 to10 membered heteroaryl, wherein optional substituent is hydroxyl,halogen, —(C₁-C₆)alkyl or —(C₁-C₆)alkoxy; R^(s) is an optionallysubstituted —(C₁-C₆)alkyl-(C₆-C₁₀)aryl, wherein the optional substituentis halogen; m is independently represents 0, 1, 2, 3 or 4; and n isindependently represents 0, 1, 2, or
 3. 11. The method of claim 10,wherein the compound of Formula (I) is

or their pharmaceutically acceptable salts, pharmaceutically acceptablsolvates or stereoisomers thereof, wherein the values of all thevariables are as described in claim
 10. 12. The method of claim 10,wherein R^(b) is hydrogen, fluorine; R³ is fluorine; or R² isindependently represents halogen, cyano or haloalkyl; R⁴ and R⁵ aremethyl, ethyl or propyl; m is 1 or 2; or R^(a) methyl, ethyl, propyl,isopropyl, butyl or tert-butyl.
 13. The method of claim 10, wherein thecompound of formula (I) is(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclohexylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-(cyclopentylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclobutylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(S)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl) sulfonyl)pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-((6-(1H-1, 2, 4-triazol-1-yl)pyridin-3-yl) sulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N—(N, N-dimethylsulfamoyl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-1),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-1),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-1),N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2);(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture);(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo [1,5-a] pyridine-3-carbonyl)amide, Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide, Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide, Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide,Sodium (4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (isopropylsulfonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,or Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide;or a pharmaceutically acceptable salt thereof, a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 14. The method ofclaim 10, wherein the compound of formula (I) is(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((3-cyanophenyl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide; (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Racemic mixture),(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-(cyclohexylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(cyclopentyl sulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(cyclobutylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a]pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((6-(1H-1, 2, 4-triazol-1-yl) pyridin-3-yl) sulfonyl)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide; (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo [1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide;(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(isopropylsulfonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide;N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II), orN—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2); or a pharmaceutically acceptable salt thereof, apharmaceutically acceptable solvate thereof or a stereoisomer thereof.15. The method of claim 10, wherein the compound of formula (I) is

or a pharmaceutically acceptable salt thereof, or a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 16. A method fortreating a cancer associated with a Trk kinase activity in a mammal inneed thereof, the method comprising administering to the mammal atherapeutically effective amount of a compound(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclohexylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-(cyclopentylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclobutylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl) pyrrolidin-1-yl)pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (S)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)-4, 4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)-4, 4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-((6-(1H-1, 2, 4-triazol-1-yl)pyridin-3-yl) sulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2);(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture);(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo [1,5-a] pyridine-3-carbonyl)amide, Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide, Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide, Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide,Sodium (4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (isopropylsulfonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide;(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((3-cyanophenyl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide; (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo [1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Racemic mixture),(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-(cyclohexylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(cyclopentyl sulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(cyclobutylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a]pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-((6-(1H-1, 2,4-triazol-1-yl) pyridin-3-yl) sulfonyl)-5-(2-(3, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide;(R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo [1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide;(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(isopropylsulfonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2),(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-methoxyethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-cyclopropyl-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methylphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamideN—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-fluoroethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-hydroxyethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(azetidin-1-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(2-cyanoethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(7-fluoro-3-(fluoromethyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(3-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(9-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-5-(2-(9-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-((1-(hydroxymethyl)cyclobutyl)methyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(azetidin-1-ylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,N-(azetidin-1-ylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,or5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,or a pharmaceutically acceptable salt thereof, a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 17. The method ofclaim 16, wherein the compound having formula

or a pharmaceutically acceptable salt thereof, or a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 18. A method oftreating a cancer in a subject, the method comprising: a) determiningthat the cancer is associated with an abnormal or deregulated Trkkinase; and b) administering to the subject a therapeutically effectiveamount of a dosage form comprising a compound(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclohexylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-(cyclopentylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(cyclobutylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-I),N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Isomer-II),(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(S)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl) phenyl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-((6-(1H-1, 2, 4-triazol-1-yl)pyridin-3-yl) sulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2);(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture);(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo [1,5-a] pyridine-3-carbonyl)amide, Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide, Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide, Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide,Sodium (4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (isopropylsulfonyl)amide, Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide;(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((3-cyanophenyl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-methylpyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-morpholinophenyl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide; (R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy) phenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Racemic mixture),(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(cyclohexyl sulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-(cyclopentylsulfonyl)-5-(2-(2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)—N-(cyclobutylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1, 5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo [1, 5-a]pyridine-3-carboxamide,Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-4-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1, 2-dimethyl-1H-imidazol-5-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2, 4-dimethylthiazol-5-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl)sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo [1, 5-a] pyridine-3-carboxamide, (R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide, (R)—N-((6-(1H-1, 2,4-triazol-1-yl) pyridin-3-yl) sulfonyl)-5-(2-(3, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo [1, 5-a] pyridine-3-carboxamide, 5-((R)-2-(3,5-difluorophenyl) pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl) sulfonyl) pyrazolo [1, 5-a] pyridine-3-carboxamide;(R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl) pyrazolo [1, 5-a]pyridine-3-carboxamide, (R)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl) pyrazolo [1,5-a] pyridine-3-carboxamide, 5-((R)-2-(2, 5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl) pyrazolo[1, 5-a] pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl)sulfonyl) pyrazolo [1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl)sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide;(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methylcyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(isopropylsulfonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide,Sodium(tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,Sodium(tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,Sodium(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,Sodium(R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amideSodium(N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide, Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-y)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-y)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-I),N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-II),N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-y)pyrazolo[1,5-a]pyridine-3-carboxamide(Diastereomer-2),(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-methoxyethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-cyclopropyl-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methylphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamideN—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-fluoroethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-(2-hydroxyethyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(azetidin-1-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-(2-cyanoethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(7-fluoro-3-(fluoromethyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-4-fluoro-2-(3-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(3-(cyclopropylmethoxy)-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2-cyclopropoxy-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-y)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-(2-(9-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N,N-dimethylsulfamoyl)-5-(2-(9-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-((1-(hydroxymethyl)cyclobutyl)methyl)-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,(R)-5-(2-(5-fluoro-2-((4-methyltetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N—(N-ethyl-N-methylsulfamoyl)-5-((2R,4S)-4-fluoro-2-(6-fluorobenzo[d][1,3]dioxol-4-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(azetidin-1-ylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,N-(azetidin-1-ylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N—(N-isobutyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,or5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-4-fluoro-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,or a pharmaceutically acceptable salt thereof, a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.
 19. The method ofclaim 18, wherein the compound having formula

or a pharmaceutically acceptable salt thereof, or a pharmaceuticallyacceptable solvate thereof or a stereoisomer thereof.